PMID- 12021716
OWN - NLM
STAT- MEDLINE
DCOM- 20020613
LR  - 20190822
IS  - 0741-5214 (Print)
IS  - 0741-5214 (Linking)
VI  - 35
IP  - 5
DP  - 2002 May
TI  - Human leukocyte antigen class II immune response genes, female gender, and 
      cigarette smoking as risk and modulating factors in abdominal aortic aneurysms.
PG  - 988-93
AB  - OBJECTIVE: Aortic inflammation and the genes that regulate the immune response 
      play an important role in abdominal aortic aneurysm pathogenesis. However, the 
      modulating effects of such genetic and other environmental factors on the 
      severity on aneurysm inflammation is not known. The objective of this study was 
      to determine the influence of the human leukocyte antigen (HLA) class II genes, 
      gender, and environmental factors on degree of abdominal aortic aneurysm tissue 
      inflammation. METHODS: Aneurysm specimens were obtained at the time of operation 
      from 96 consecutive patients who underwent abdominal aortic aneurysm repair and 
      were graded for degree of histologic inflammation. Multivariate analysis was used 
      to determine the association of genetic and environmental factors with degree of 
      inflammation and to determine the HLA-associated disease risk for aneurysm. 
      RESULTS: Active cigarette smoking and female gender were independently associated 
      with high-grade tissue inflammation identified histologically (odds ratio [OR], 
      confidence interval [CI]: 5.6, 1.6 to 19.3; and 6.0, 1.4 to 26.2, respectively), 
      and a specific HLA allele (DR B1(*)01) was inversely associated with inflammation 
      (OR, CI: 0.2, 0.04 to 0.7). Overall, the HLA-DR B1(*)02 and B1(*)04 alleles were 
      significantly associated with disease risk, more than doubling risk for abdominal 
      aortic aneurysm (OR, CI: 2.5, 1.4 to 4.3; and 2.1, 1.2 to 3.7, respectively). 
      CONCLUSION: Active cigarette smoking and female gender are significant 
      disease-modulating factors associated with increased abdominal aortic aneurysm 
      inflammation. In addition, the HLA class II immune response genes possess both 
      disease modulating and disease risk properties, which may be useful in early 
      aneurysm detection and surveillance.
FAU - Rasmussen, Todd E
AU  - Rasmussen TE
AD  - Department of Surgery, Uniformed Services University of Health Sciences, Malcolm 
      Grow USAF Medical Center, Andrews Air Force Base, MD 20762, USA.
FAU - Hallett, John W Jr
AU  - Hallett JW Jr
FAU - Tazelaar, Henry D
AU  - Tazelaar HD
FAU - Miller, Virginia M
AU  - Miller VM
FAU - Schulte, Stephanie
AU  - Schulte S
FAU - O'Fallon, W Michael
AU  - O'Fallon WM
FAU - Weyand, Cornelia M
AU  - Weyand CM
LA  - eng
GR  - R01 AI 44142/AI/NIAID NIH HHS/United States
GR  - R01 AR 42527/AR/NIAMS NIH HHS/United States
GR  - R01 EY 11916/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Vasc Surg
JT  - Journal of vascular surgery
JID - 8407742
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Aortic Aneurysm, Abdominal/*etiology/*genetics/immunology
MH  - Female
MH  - Genes, MHC Class II/*genetics/immunology
MH  - HLA Antigens/*genetics/immunology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Sex Factors
MH  - Smoking/*adverse effects/*genetics/immunology
EDAT- 2002/05/22 10:00
MHDA- 2002/06/14 10:01
CRDT- 2002/05/22 10:00
PHST- 2002/05/22 10:00 [pubmed]
PHST- 2002/06/14 10:01 [medline]
PHST- 2002/05/22 10:00 [entrez]
AID - S0741521402274534 [pii]
AID - 10.1067/mva.2002.121753 [doi]
PST - ppublish
SO  - J Vasc Surg. 2002 May;35(5):988-93. doi: 10.1067/mva.2002.121753.