PMID- 12021922
OWN - NLM
STAT- MEDLINE
DCOM- 20020726
LR  - 20041117
IS  - 0945-6317 (Print)
IS  - 0945-6317 (Linking)
VI  - 440
IP  - 5
DP  - 2002 May
TI  - Translocation of the HMGI-C ( HMGA2) gene in a benign mesenchymoma 
      (chondrolipoangioma).
PG  - 485-90
AB  - Mesenchymomas are neoplasms in which there are at least two types of 
      differentiated cells of mesenchymal derivation other than fibrous tissue. 
      Chondrolipoangioma is a rare type of mesenchymoma composed predominantly of 
      cartilage and adipose tissue with vascular elements and myxoid tissue present in 
      lesser proportions. Cytogenetic analysis was performed on a case of 
      chondrolipoangioma and revealed a t(12;15) (q13;q26) as the sole chromosome 
      abnormality in 40 metaphases analyzed. However, using fluorescence in situ 
      hybridization (FISH) analysis, a complex rearrangement was found involving 
      chromosomes 2, 12, and 15, with a cryptic rearrangement of the gene ( HMGI-C; 
      HMGA2) coding for high-mobility group I protein. This finding suggests a role for 
      the HMGI-C gene also in the pathogenesis of this uncommon benign tumor type, in 
      addition to its well-established role in the pathogenesis of common benign tumors 
      such as lipomas, uterine leiomyomas, pulmonary chondroid hamartomas, and 
      endometrial polyps.
FAU - Van Dorpe, Jo
AU  - Van Dorpe J
AD  - Department of Pathology, University Hospital St-Raphael, Leuven Catholic 
      University, Minderbroederstraat 12, 3000 Leuven, Belgium.
FAU - Dal Cin, Paola
AU  - Dal Cin P
FAU - Weremowicz, Stanislawa
AU  - Weremowicz S
FAU - Van Leuven, Fred
AU  - Van Leuven F
FAU - de Wever, Ivo
AU  - de Wever I
FAU - Van den Berghe, Herman
AU  - Van den Berghe H
FAU - Fletcher, Christopher D M
AU  - Fletcher CD
FAU - Sciot, Raf
AU  - Sciot R
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20011107
PL  - Germany
TA  - Virchows Arch
JT  - Virchows Archiv : an international journal of pathology
JID - 9423843
RN  - 0 (Actins)
RN  - 0 (Desmin)
RN  - 0 (HMGA2 Protein)
RN  - 0 (S100 Proteins)
SB  - IM
MH  - Actins/analysis
MH  - Biopsy
MH  - Chromosomes, Human, Pair 12
MH  - Chromosomes, Human, Pair 15
MH  - Desmin/analysis
MH  - HMGA2 Protein/*genetics
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Male
MH  - Mesenchymoma/*genetics/pathology
MH  - Middle Aged
MH  - Muscle Neoplasms/*genetics/pathology
MH  - S100 Proteins/analysis
MH  - *Translocation, Genetic
EDAT- 2002/05/22 10:00
MHDA- 2002/07/27 10:01
CRDT- 2002/05/22 10:00
PHST- 2001/07/25 00:00 [received]
PHST- 2001/09/05 00:00 [accepted]
PHST- 2002/05/22 10:00 [pubmed]
PHST- 2002/07/27 10:01 [medline]
PHST- 2002/05/22 10:00 [entrez]
AID - 10.1007/s00428-001-0547-z [doi]
PST - ppublish
SO  - Virchows Arch. 2002 May;440(5):485-90. doi: 10.1007/s00428-001-0547-z. Epub 2001 
      Nov 7.