PMID- 12022754
OWN - NLM
STAT- MEDLINE
DCOM- 20021129
LR  - 20191210
IS  - 1073-2322 (Print)
IS  - 1073-2322 (Linking)
VI  - 17
IP  - 5
DP  - 2002 May
TI  - Effect of abdominal infections on peritoneal and systemic production of 
      interleukin 6 and monocyte chemoattractant protein-1.
PG  - 361-4
AB  - The aim of the study was to compare peritoneal and systemic production of 
      interleukin 6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1) in uninfected 
      patients and in patients with peritonitis. Peritoneum was excised at laparotomy 
      for acute peritonitis (n = 22) or noninfectious reasons (n = 61), and was 
      incubated with or without lipopolysaccharide (LPS). Mediator concentrations in 
      the culture-supernatants, in the patients' serum, and in plasmasupernatants of 
      LPS-stimulated whole blood were related to outcome. Spontaneous production of 
      IL-6 by the peritoneum was increased in infected patients compared with 
      uninfected patients. In contrast to IL-6, LPS-stimulated production of MCP-1 was 
      significantly less in infected patients. Serum concentrations of both mediators 
      were higher in infected patients and the highest concentrations of MCP-1 were in 
      patients who died. LPS-stimulated production of IL-6 in whole blood was least, 
      whereas that of MCP-1 was greatest in infected patients who died. These 
      contrasting results for local and systemic production of mediators illustrate the 
      compartmentalized immune response to intra-abdominal infection.
FAU - Riese, Jutta
AU  - Riese J
AD  - Department of Surgery, University of Erlangen-Nuremberg, Germany.
FAU - Schoolmann, Sven
AU  - Schoolmann S
FAU - Denzel, Christian
AU  - Denzel C
FAU - Herrmann, Olaf
AU  - Herrmann O
FAU - Hohenberger, Werner
AU  - Hohenberger W
FAU - Haupt, Werner
AU  - Haupt W
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Shock
JT  - Shock (Augusta, Ga.)
JID - 9421564
RN  - 0 (Chemokine CCL2)
RN  - 0 (Interleukin-6)
RN  - 0 (Lipopolysaccharides)
SB  - IM
MH  - Blood/metabolism
MH  - Chemokine CCL2/*blood
MH  - Female
MH  - Humans
MH  - Infections/immunology/*metabolism
MH  - Interleukin-6/*blood
MH  - Lipopolysaccharides
MH  - Male
MH  - Middle Aged
MH  - Organ Culture Techniques
MH  - Peritoneum/metabolism
MH  - Peritonitis/immunology/*metabolism/surgery
MH  - Survival Rate
MH  - Treatment Outcome
EDAT- 2002/05/23 10:00
MHDA- 2002/11/30 04:00
CRDT- 2002/05/23 10:00
PHST- 2002/05/23 10:00 [pubmed]
PHST- 2002/11/30 04:00 [medline]
PHST- 2002/05/23 10:00 [entrez]
AID - 10.1097/00024382-200205000-00003 [doi]
PST - ppublish
SO  - Shock. 2002 May;17(5):361-4. doi: 10.1097/00024382-200205000-00003.