PMID- 12023759
OWN - NLM
STAT- MEDLINE
DCOM- 20020709
LR  - 20071114
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 185
IP  - 11
DP  - 2002 Jun 1
TI  - Associations between human leukocyte antigen homozygosity and antibody levels to 
      measles vaccine.
PG  - 1545-9
AB  - The association between human leukocyte antigen (HLA) homozygosity and measles 
      antibody levels was assessed in a volunteer group of 242 children. Serum samples 
      were tested for measles IgG antibodies, class I and class II HLA alleles were 
      typed, and associations were examined between HLA homozygosity and antibody 
      levels. Children who were homozygous for at least 1 locus were twice as likely to 
      be seronegative (odds ratio, 1.97; 95% confidence interval, 1.08-3.61). Children 
      who were homozygous at >/=1 loci were increasingly likely to be seronegative 
      (chi(2) test for trend; P=.02). When serum antibody levels were examined as 
      continuous variables, children who were homozygous at certain loci tended to have 
      lower mean antibody levels. These results suggest that lack of HLA diversity may 
      limit the range of peptides that can be presented to antibody-producing cells, 
      potentially resulting in a decreased immune response to viral infections.
FAU - St Sauver, Jennifer L
AU  - St Sauver JL
AD  - Section of Clinical Epidemiology, Department of Health Sciences Research, Vaccine 
      Research Group, Mayo Clinic Rochester, 200 First Street SW, Rochester, MN 55905, 
      USA. ststauver.jennifer@mayo.edu
FAU - Ovsyannikova, Inna G
AU  - Ovsyannikova IG
FAU - Jacobson, Robert M
AU  - Jacobson RM
FAU - Jacobsen, Steven J
AU  - Jacobsen SJ
FAU - Vierkant, Robert A
AU  - Vierkant RA
FAU - Schaid, Daniel J
AU  - Schaid DJ
FAU - Pankratz, V Shane
AU  - Pankratz VS
FAU - Green, Erin M
AU  - Green EM
FAU - Poland, Gregory A
AU  - Poland GA
LA  - eng
GR  - AI 33144/AI/NIAID NIH HHS/United States
GR  - AI 435240/AI/NIAID NIH HHS/United States
GR  - AR 30582/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20020509
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Antibodies, Viral)
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Measles Vaccine)
SB  - IM
MH  - Adolescent
MH  - Alleles
MH  - Antibodies, Viral/*blood
MH  - Child
MH  - Child, Preschool
MH  - HLA Antigens/*genetics
MH  - Histocompatibility Antigens Class I/genetics
MH  - Histocompatibility Antigens Class II/genetics
MH  - Histocompatibility Testing
MH  - *Homozygote
MH  - Humans
MH  - Immunoglobulin G/blood
MH  - Measles Vaccine/*immunology
MH  - Measles virus/immunology
EDAT- 2002/05/23 10:00
MHDA- 2002/07/10 10:01
CRDT- 2002/05/23 10:00
PHST- 2001/08/10 00:00 [received]
PHST- 2002/01/09 00:00 [revised]
PHST- 2002/05/23 10:00 [pubmed]
PHST- 2002/07/10 10:01 [medline]
PHST- 2002/05/23 10:00 [entrez]
AID - JID010966 [pii]
AID - 10.1086/340573 [doi]
PST - ppublish
SO  - J Infect Dis. 2002 Jun 1;185(11):1545-9. doi: 10.1086/340573. Epub 2002 May 9.