PMID- 12028538
OWN - NLM
STAT- MEDLINE
DCOM- 20021209
LR  - 20190826
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 59
IP  - 2
DP  - 2002 Feb
TI  - Sequencing-based typing of HLA-B*51 alleles and the significant association of 
      HLA-B*5101 and -B*5108 with Behcet's disease in Greek patients.
PG  - 118-21
AB  - Behcet's disease (BD) is widely known to be strongly associated with human 
      leukocyte antigen (HLA) B51 in many different ethnic groups.Recently, HLA-B51 
      allele typing of Greek BD patients was performed to study the distribution of 
      B*5101-B*5107 alleles in this Greek population, the B51 antigen strongly 
      associated with BD was found to be predominantly encoded by allele B*5101. As it 
      is now known that the B51 antigen can be encoded by 21 alleles, B*5101-B*5121, we 
      performed HLA-B*51 allele genotyping among 58 Greek patients with BD. After 
      serological HLA typing, typing of HLA-B*51 alleles was performed using the 
      polymerase chain reaction-sequencing-based typing (PCR-SBT) method. The frequency 
      of the B51 antigen was found to be significantly higher in the patient group as 
      compared with the control group (75.9% of patients vs 22.0% of controls. In the 
      genotyping of B51 alleles, 34 out of 44 B51-positive patients possessed B*5101, 
      13 out of the 44 carried B*5108. In contrast, all of the 9 B51-positive normal 
      controls carried B*5101. This study revealed a strong association between Greeks 
      with BD, both B*5101, B*5108, provided important insights into the molecular 
      mechanism underlying the association between HLA status, this disease.
FAU - Mizuki, N
AU  - Mizuki N
AD  - Department of Ophthalmology, Yokohama City University School of Medicine, Japan.
FAU - Ota, M
AU  - Ota M
FAU - Katsuyama, Y
AU  - Katsuyama Y
FAU - Yabuki, K
AU  - Yabuki K
FAU - Ando, H
AU  - Ando H
FAU - Shiina, T
AU  - Shiina T
FAU - Palimeris, G D
AU  - Palimeris GD
FAU - Kaklamani, E
AU  - Kaklamani E
FAU - Ito, D
AU  - Ito D
FAU - Ohno, S
AU  - Ohno S
FAU - Inoko, Hidetoshi
AU  - Inoko H
LA  - eng
PT  - Journal Article
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-B51 Antigen)
SB  - IM
MH  - *Alleles
MH  - Behcet Syndrome/ethnology/*genetics
MH  - Greece/ethnology
MH  - HLA-B Antigens/analysis/*genetics/immunology
MH  - HLA-B51 Antigen
MH  - Histocompatibility Testing/methods
MH  - Humans
MH  - Molecular Sequence Data
MH  - Polymerase Chain Reaction
MH  - Sequence Analysis, DNA
EDAT- 2002/05/25 10:00
MHDA- 2002/12/10 04:00
CRDT- 2002/05/25 10:00
PHST- 2002/05/25 10:00 [pubmed]
PHST- 2002/12/10 04:00 [medline]
PHST- 2002/05/25 10:00 [entrez]
AID - tan590207 [pii]
AID - 10.1034/j.1399-0039.2002.590207.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2002 Feb;59(2):118-21. doi: 10.1034/j.1399-0039.2002.590207.x.