PMID- 12028566
OWN - NLM
STAT- MEDLINE
DCOM- 20020708
LR  - 20190818
IS  - 0300-9475 (Print)
IS  - 0300-9475 (Linking)
VI  - 55
IP  - 6
DP  - 2002 Jun
TI  - Phenotypic study of peripheral blood leucocytes in HTLV-I-infected individuals 
      from Minas Gerais, Brazil.
PG  - 621-8
AB  - The human T-cell lymphotropic virus type I (HTLV-I)-associated 
      myelopathy/tropical spastic paraparesis (HAM/TSP) associated with the HTLV-I is a 
      well-defined clinical-pathological entity in which the virus and host immune 
      responses contribute to the pathological mechanism. In this study, flow 
      cytometric analysis of whole peripheral blood leucocytes (PBL) was performed to 
      evaluate the immunological status of HTLV-I-infected individuals in an effort to 
      better understand the role of the immune system in the development of HAM/TSP. We 
      have evaluated three groups of infected patients including asymptomatic (AS = 
      18), ambulatory/oligosymptomatic (AM = 14) and hospitalized HAM/TSP individuals 
      (HO = 42). Noninfected healthy blood donors were used for the control group (NI = 
      32). Our results demonstrated that the HO group presents an increased percentage 
      of circulating T cells and a decreased percentage of B and natural killer (NK) 
      cells, leading to the highest T/B-cell ratio in comparison with the other groups. 
      Interestingly, while an increased percentage of activated CD4+HLA-DR+ T 
      lymphocytes was observed in both AM and HO, only HO presented higher percentage 
      of activated CD8+HLA-DR+ in combination with the highest CD18 surface expression. 
      This was true for all cell populations analysed, including T lymphocytes, 
      monocytes and neutrophils. Moreover, the HO group was distinguished by a dramatic 
      decrease in the percentage of CD8+CD28+ lymphocytes. Taken together, these 
      findings demonstrate a potent cellular immune activation response involving 
      primarily CD8+ T cells that is concomitant with disease progression in HAM/TSP. 
      We also show that an upregulation of CD18 expression, a hallmark for increased 
      cell migratory potential, might play a critical role in the 
      development/maintenance of HAM/TSP.
FAU - Brito-Melo, G E A
AU  - Brito-Melo GE
AD  - Laboratorio de Doenca de Chagas - CPqRR-FIOCRUZ/BH, Minas Gerais, Brazil.
FAU - Martins-Filho, O A
AU  - Martins-Filho OA
FAU - Carneiro-Proietti, A B F
AU  - Carneiro-Proietti AB
FAU - Catalan-Soares, B
AU  - Catalan-Soares B
FAU - Ribas, J G
AU  - Ribas JG
FAU - Thorum, G W
AU  - Thorum GW
FAU - Barbosa-Stancioli, E F
AU  - Barbosa-Stancioli EF
CN  - Grupo Interdisciplinar de Pesquisas Em HTLV
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Scand J Immunol
JT  - Scandinavian journal of immunology
JID - 0323767
RN  - 0 (CD18 Antigens)
RN  - 0 (CD28 Antigens)
SB  - IM
MH  - Adult
MH  - Brazil
MH  - CD18 Antigens/biosynthesis
MH  - CD28 Antigens/biosynthesis
MH  - CD4-Positive T-Lymphocytes/immunology
MH  - CD8-Positive T-Lymphocytes/immunology
MH  - Cross-Sectional Studies
MH  - Female
MH  - Flow Cytometry
MH  - HTLV-I Infections/*blood/complications/immunology
MH  - Human T-lymphotropic virus 1/*immunology
MH  - Humans
MH  - Leukocytes/*immunology
MH  - Lymphocyte Activation/immunology
MH  - Male
MH  - Middle Aged
MH  - Paraparesis, Tropical Spastic/*blood/complications/immunology
MH  - T-Lymphocyte Subsets/immunology
EDAT- 2002/05/25 10:00
MHDA- 2002/07/09 10:01
CRDT- 2002/05/25 10:00
PHST- 2002/05/25 10:00 [pubmed]
PHST- 2002/07/09 10:01 [medline]
PHST- 2002/05/25 10:00 [entrez]
AID - 1087 [pii]
AID - 10.1046/j.1365-3083.2002.01087.x [doi]
PST - ppublish
SO  - Scand J Immunol. 2002 Jun;55(6):621-8. doi: 10.1046/j.1365-3083.2002.01087.x.