PMID- 12028806
OWN - NLM
STAT- MEDLINE
DCOM- 20020619
LR  - 20191025
IS  - 0895-8378 (Print)
IS  - 0895-8378 (Linking)
VI  - 14
IP  - 5
DP  - 2002 May
TI  - Effects of aerosols from nontoxic Stachybotrys chartarum on murine airways.
PG  - 521-40
AB  - Acute effects on the upper and lower respiratory tract due to inhalation exposure 
      to Stachybotrys chartarum (Sc) extract were investigated in mice. In addition, 
      the capacity of the Sc exposure to activate immune system and cause inflammation 
      in the respiratory tract was studied. The inhalation of Sc extract aerosols was 
      observed to provoke sensory irritation in the airways of both naive and 
      Sc-immunized mice. In contrast, exposure to aerosolized ovalbumin or phosphate 
      buffered saline did not cause this effect. Exposure to Sc twice a week for 3 wk 
      increased significantly the serum total immunoglobulin E (IgE) levels in BALB/c 
      mice immunized with Sc as well as in nonimmunized mice. A slight presence of 
      inflammatory cells was observed in the alveoli 3 days after the last exposure to 
      Sc. In conclusion, Sc extract has the capacity to provoke sensory irritation in 
      the murine airways and to activate the murine immune system.
FAU - Korpi, Anne
AU  - Korpi A
AD  - Department of Environmental Sciences, Research and Development Unit of 
      Environmental Health, University of Kuopio, Bioteknia 2, PO Box 1627, 70211 
      Kuopio, Finland. anne.korpi@uku.fi
FAU - Kasanen, J-P
AU  - Kasanen JP
FAU - Raunio, P
AU  - Raunio P
FAU - Kosma, V-M
AU  - Kosma VM
FAU - Virtanen, T
AU  - Virtanen T
FAU - Pasanen, A-L
AU  - Pasanen AL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Inhal Toxicol
JT  - Inhalation toxicology
JID - 8910739
RN  - 0 (Aerosols)
SB  - IM
MH  - Aerosols/adverse effects
MH  - Animals
MH  - Immune System/drug effects
MH  - Immunization
MH  - Inflammation/*pathology
MH  - *Inhalation Exposure
MH  - Mice
MH  - Pulmonary Alveoli/immunology/*pathology
MH  - Stachybotrys/*chemistry
EDAT- 2002/05/25 10:00
MHDA- 2002/06/20 10:01
CRDT- 2002/05/25 10:00
PHST- 2002/05/25 10:00 [pubmed]
PHST- 2002/06/20 10:01 [medline]
PHST- 2002/05/25 10:00 [entrez]
AID - 10.1080/089583701753678607 [doi]
PST - ppublish
SO  - Inhal Toxicol. 2002 May;14(5):521-40. doi: 10.1080/089583701753678607.