PMID- 12028869
OWN - NLM
STAT- MEDLINE
DCOM- 20020912
LR  - 20041117
IS  - 1401-7431 (Print)
IS  - 1401-7431 (Linking)
VI  - 36
IP  - 2
DP  - 2002 Mar
TI  - Cardiorespiratory response to exercise in children after modified fontan 
      operation.
PG  - 80-5
AB  - OBJECTIVE: Examination of exercise function of Fontan patients and comparison 
      with healthy control subjects. DESIGN: Fourteen patients (6 males, 8 females; 
      age: 5.7-17 years, mean 8.1 years) after Fontan repair in New York Heart 
      Association (NYHA) class I with rest O(2)sat > 85% requiring no cardiovascular 
      medications performed graded exercises on a treadmill 0.5-3.2 years 
      postoperatively (mean 1.8 years). During the tests the heart and respiratory 
      rate, blood pressure, oxygen uptake, carbon dioxide production, minute 
      ventilation, tidal volume and O(2)sat were recorded. Spirometry was performed 
      before and during exercise. RESULTS: The peak VO(2)max in Fontan patients was 
      significantly reduced compared with controls (p = 0.0002). Other parameters: 
      anaerobic threshold (p = 0.0001); pulsO(2) (p = 0.00005); peak minute ventilation 
      (p = 0.0014); physiological dead space to tidal volume ratio at peak exercise (p 
      = 0.0004); maximal work rate (p = 0.00008); exercise time (p = 0.00003) were 
      significantly reduced in univentricular patients. The heart rate at peak exercise 
      was lower in the patients (p = 0.0003) and O(2)sat dropped significantly (p = 
      0.003). CONCLUSION: The aerobic capacity, work and ventilatory parameters in 
      Fontan patients are markedly reduced compared with controls. The anaerobic 
      threshold was significantly lower. The decreased O(2)sat at peak exercise may 
      suggest intrapulmonary shunting.
FAU - Zajac, Andrzej
AU  - Zajac A
AD  - Department of Pediatric Cardiac Surgery, Polish-American Children's Hospital, 
      Krakow, Poland.
FAU - Tomkiewicz, Lidia
AU  - Tomkiewicz L
FAU - Podolec, Piotr
AU  - Podolec P
FAU - Tracz, Wieslawa
AU  - Tracz W
FAU - Malec, Edward
AU  - Malec E
LA  - eng
PT  - Journal Article
PL  - England
TA  - Scand Cardiovasc J
JT  - Scandinavian cardiovascular journal : SCJ
JID - 9708377
SB  - IM
CIN - Scand Cardiovasc J. 2002 Mar;36(2):67-8. PMID: 12028865
MH  - Adolescent
MH  - Anaerobic Threshold
MH  - Blood Pressure
MH  - Child
MH  - Child, Preschool
MH  - *Exercise Test
MH  - Female
MH  - *Fontan Procedure
MH  - Heart/*physiopathology
MH  - Heart Defects, Congenital/*physiopathology/surgery
MH  - Heart Rate
MH  - Humans
MH  - Lung/*physiopathology
MH  - Male
MH  - Oxygen Consumption
MH  - Sinoatrial Node/physiopathology
MH  - Spirometry
EDAT- 2002/05/25 10:00
MHDA- 2002/09/13 10:01
CRDT- 2002/05/25 10:00
PHST- 2002/05/25 10:00 [pubmed]
PHST- 2002/09/13 10:01 [medline]
PHST- 2002/05/25 10:00 [entrez]
AID - 10.1080/140174302753675348 [doi]
PST - ppublish
SO  - Scand Cardiovasc J. 2002 Mar;36(2):80-5. doi: 10.1080/140174302753675348.