PMID- 12030432
OWN - NLM
STAT- MEDLINE
DCOM- 20030805
LR  - 20041117
IS  - 0145-5680 (Print)
IS  - 0145-5680 (Linking)
VI  - 48
IP  - 3
DP  - 2002 May
TI  - Autoantibodies against golgi apparatus induced by arteriviruses.
PG  - 279-84
AB  - Members of the genus Arterivirus within the monogeneric family Arteriviridae are 
      lactate dehydrogenase-elvating virus (LDV), porcine reproductive and respiratory 
      syndrome virus (PRRSV), equine arteritis virus (EAV) and simian hemorrhagic fever 
      virus. In LDV-infected mice the appearance of autoantibodies against 
      Golgi-antigen dominated the early immune response. Shared antigenicity between 
      LDV and Golgi-antigen of normal cells could not be demonstrated. Monoclonal 
      antibodies (MAbs) reacted either with LDV or with Golgi-antigen but not with 
      both. Immunization of mice with the porcine arterivirus PRRSV, however, led to 
      the establishment of MAbs that recognized the structural glycoprotein GP3 as well 
      as Golgi-antigen of normal porcine cells indicating molecular mimicry of viral 
      and cellular antigen. In addition to cross-reactive antibodies MAbs solely 
      reactive with Golgi-antigen were observed. After immunization of mice with EAV, 
      the equine arterivirus, clones were isolated producing Golgi-antigen recognizing 
      autoantibodies. Morphogenesis of arteriviruses occurs in the Golgi region. The 
      autoimmune responses following immunization with arteriviruses may offer an 
      approach for determining the mechanism by which such responses develop and become 
      of biologic importance.
FAU - Weiland, Emilie
AU  - Weiland E
AD  - Federal Research Centre for Virus Diseases of Animals, Tubingen, Germany. 
      E.Weiland@tue.bfav.de
FAU - Weiland, Frank
AU  - Weiland F
LA  - eng
PT  - Journal Article
PL  - France
TA  - Cell Mol Biol (Noisy-le-grand)
JT  - Cellular and molecular biology (Noisy-le-Grand, France)
JID - 9216789
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Autoantibodies)
RN  - 0 (GP3 protein, equine arteritis virus)
RN  - 0 (Viral Envelope Proteins)
SB  - IM
MH  - 3T3 Cells
MH  - Animals
MH  - Antibodies, Monoclonal/immunology
MH  - Arterivirus/*immunology/ultrastructure
MH  - Autoantibodies/*immunology
MH  - Cell Line
MH  - Cross Reactions
MH  - Fluorescent Antibody Technique
MH  - Golgi Apparatus/*immunology
MH  - HeLa Cells
MH  - Humans
MH  - Lactate dehydrogenase-elevating virus/immunology
MH  - Macrophages/immunology/ultrastructure
MH  - Mice
MH  - Porcine respiratory and reproductive syndrome virus/immunology
MH  - Viral Envelope Proteins/immunology
EDAT- 2002/05/28 10:00
MHDA- 2003/08/06 05:00
CRDT- 2002/05/28 10:00
PHST- 2002/05/28 10:00 [pubmed]
PHST- 2003/08/06 05:00 [medline]
PHST- 2002/05/28 10:00 [entrez]
PST - ppublish
SO  - Cell Mol Biol (Noisy-le-grand). 2002 May;48(3):279-84.