PMID- 12030604
OWN - NLM
STAT- MEDLINE
DCOM- 20021211
LR  - 20181113
IS  - 0391-4097 (Print)
IS  - 0391-4097 (Linking)
VI  - 25
IP  - 4
DP  - 2002 Apr
TI  - Platelet cyclic guanosine monophosphate production during menstrual cycle in 
      healthy women.
PG  - 334-7
AB  - The incidence of cardiovascular disease among women during their reproductive 
      years is considerably less than in men and this difference decreases after 
      menopause. Since in cultured endothelial cells and in platelets E2 increases 
      nitric oxide (NO) production, it is possible that their cardioprotective effect 
      may be mediated by NO. The aim of this study was to evaluate platelet cyclic 
      guanosine monophosphate (cGMP), as a marker of NO production, during menstrual 
      cycle. Fifteen women aged 26-40 yr were studied to evaluate: LH, FSH, E2, P and 
      cGMP on the 5th follicular and 22nd luteal day of the cycle and during the 
      ovulatory period. Platelet cGMP was evaluated in basal condition (3-isobuthyl 
      1-methylxanthine-IBMX) and with ionomycine (IONO) and sodium nitroprusside (SNP). 
      RESULTS: LH, FSH, E2 and P demonstrated the typical patterns of ovulatory cycle. 
      During follicular and luteal IBMX, SNP and IONO phase were homogeneous while they 
      increased during the ovulatory period. A correlation between IBMX cGMP and E2 
      (p<0.002, rs=0.456) was found. In conclusion the data show an increase in 
      platelet cGMP during the ovulatory period and a correlation between E2 and cGMP 
      suggesting that E2 modulates NO production. The cardioprotective effect of E2 may 
      be, at least in part, mediated by the increase in NO production.
FAU - Martina, V
AU  - Martina V
AD  - Department of Internal Medicine, University of Turin, Italy. 
      martinavalentino@hotmail.com
FAU - Bruno, G A
AU  - Bruno GA
FAU - Zumpano, E
AU  - Zumpano E
FAU - Origlia, C
AU  - Origlia C
FAU - Ferri, M
AU  - Ferri M
FAU - Pescarmona, G P
AU  - Pescarmona GP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Italy
TA  - J Endocrinol Invest
JT  - Journal of endocrinological investigation
JID - 7806594
RN  - 0 (Ionophores)
RN  - 0 (Nitric Oxide Donors)
RN  - 169D1260KM (Nitroprusside)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 4TI98Z838E (Estradiol)
RN  - 56092-81-0 (Ionomycin)
RN  - H2D2X058MU (Cyclic GMP)
RN  - TBT296U68M (1-Methyl-3-isobutylxanthine)
SB  - IM
MH  - 1-Methyl-3-isobutylxanthine/pharmacology
MH  - Adult
MH  - Blood Platelets/*metabolism
MH  - Cyclic GMP/*blood
MH  - Estradiol/blood
MH  - Female
MH  - Follicular Phase/blood
MH  - Humans
MH  - Ionomycin/pharmacology
MH  - Ionophores/pharmacology
MH  - Luteal Phase/blood
MH  - Menstrual Cycle/*blood
MH  - Nitric Oxide/biosynthesis
MH  - Nitric Oxide Donors/pharmacology
MH  - Nitroprusside/pharmacology
MH  - Ovulation/blood
MH  - Reference Values
EDAT- 2002/05/28 10:00
MHDA- 2002/12/12 04:00
CRDT- 2002/05/28 10:00
PHST- 2002/05/28 10:00 [pubmed]
PHST- 2002/12/12 04:00 [medline]
PHST- 2002/05/28 10:00 [entrez]
AID - 5981 [pii]
AID - 10.1007/BF03344014 [doi]
PST - ppublish
SO  - J Endocrinol Invest. 2002 Apr;25(4):334-7. doi: 10.1007/BF03344014.