PMID- 12031517
OWN - NLM
STAT- MEDLINE
DCOM- 20021030
LR  - 20190822
IS  - 0378-5955 (Print)
IS  - 0378-5955 (Linking)
VI  - 165
IP  - 1-2
DP  - 2002 Mar
TI  - Temporal integration in the human auditory cortex as represented by the 
      development of the steady-state magnetic field.
PG  - 68-84
AB  - The threshold for detecting amplitude modulation (AM) decreases with increasing 
      duration of the AM sound up to several hundred milliseconds. If the auditory 
      evoked steady-state response (SSR) to AM sound is an electrophysiological 
      correlate of AM processing in the human brain, the development of the SSR should 
      follow this course of temporal integration. Magnetoencephalographic recordings of 
      SSR to 40 Hz AM tone-bursts were compared with responses to non-modulated 
      tone-bursts at inter-stimulus intervals (ISIs) of 3, 1, and 0.5 s. Both types of 
      stimuli elicited a transient gamma-band response (GBR), an N1 wave, and a 
      sustained field (SF) during stimulus presentation. The AM stimulus evoked an 
      additional 40 Hz SSR. The N1 amplitude was strongly reduced with shortened ISI, 
      whereas the amplitudes of SSR, GBR, and SF were little affected by the ISI. 
      Magnetic source-localization procedures estimated the generators of the early 
      GBR, the SSR, and the SF to be anterior and medial to the sources of the N1. The 
      sources of the SSR were in primary auditory cortex and separate from GBR sources. 
      The SSR amplitude increased monotonically over a 200 ms period beginning about 40 
      ms after stimulus onset. The time course of the SSR phase reliably measured the 
      duration of this transition to the steady state. At stimulus offset the SSR 
      ceased within 50 ms. These results indicate that the primary auditory cortex 
      responds immediately to stimulus changes and integrates stimulus features over a 
      period of about 200 ms.
FAU - Ross, Bernhard
AU  - Ross B
AD  - Institute of Experimental Audiology, Munster University Hospital, Germany. 
      bernhard.ross@ieee.org
FAU - Picton, Terence W
AU  - Picton TW
FAU - Pantev, Christo
AU  - Pantev C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Hear Res
JT  - Hearing research
JID - 7900445
SB  - IM
MH  - Acoustic Stimulation/methods
MH  - Adult
MH  - Auditory Cortex/*physiology
MH  - Evoked Potentials, Auditory/physiology
MH  - Female
MH  - Homeostasis
MH  - Humans
MH  - *Magnetoencephalography
MH  - Male
MH  - Reaction Time
MH  - Time Factors
EDAT- 2002/05/29 10:00
MHDA- 2002/11/01 04:00
CRDT- 2002/05/29 10:00
PHST- 2002/05/29 10:00 [pubmed]
PHST- 2002/11/01 04:00 [medline]
PHST- 2002/05/29 10:00 [entrez]
AID - S037859550200285X [pii]
AID - 10.1016/s0378-5955(02)00285-x [doi]
PST - ppublish
SO  - Hear Res. 2002 Mar;165(1-2):68-84. doi: 10.1016/s0378-5955(02)00285-x.