PMID- 12031545
OWN - NLM
STAT- MEDLINE
DCOM- 20020814
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 941
IP  - 1-2
DP  - 2002 Jun 21
TI  - Modulation of neurotransmitter release induced by brain-derived neurotrophic 
      factor in rat brain striatal slices in vitro.
PG  - 34-42
AB  - This study examined the influence of brain-derived neurotrophic factor (BDNF) on 
      the basal and depolarisation-induced release of the neurotransmitters GABA, 
      dopamine and serotonin from rat striatal brain slices in vitro. BDNF potentiated 
      the potassium or veratrine-stimulated release of GABA, dopamine and serotonin. 
      This potentiation was shown to be dependent on activation of the high-affinity 
      tyrosine kinase-linked receptor TrkB, as K252a (a potent TrkB antagonist) largely 
      prevented the effects. BDNF potentiated the release of each neurotransmitter to 
      similar extents irrespective of the type of depolarising stimulus used. In all 
      cases the potentiation of neurotransmitter release caused by BDNF was dependent 
      on membrane depolarisation as BDNF alone was incapable of causing potentiation. 
      These results, obtained using striatal slices in vitro, suggest that BDNF may be 
      acting via the specific receptor TrkB to modulate synaptic performance in the 
      corpus striatum in vivo.
FAU - Goggi, Julian
AU  - Goggi J
AD  - Department of Biochemistry, Imperial College of Science, Technology and Medicine, 
      South Kensington, London SW7 2AY, UK.
FAU - Pullar, Ian A
AU  - Pullar IA
FAU - Carney, Stephen L
AU  - Carney SL
FAU - Bradford, Henry F
AU  - Bradford HF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Carbazoles)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Indole Alkaloids)
RN  - 333DO1RDJY (Serotonin)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
RN  - 97161-97-2 (staurosporine aglycone)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism/pharmacology
MH  - Carbazoles/pharmacology
MH  - Corpus Striatum/drug effects/*metabolism
MH  - Dopamine/*metabolism
MH  - Enzyme Inhibitors/pharmacology
MH  - Female
MH  - Indole Alkaloids
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Serotonin/*metabolism
MH  - gamma-Aminobutyric Acid/*metabolism
EDAT- 2002/05/29 10:00
MHDA- 2002/08/15 10:01
CRDT- 2002/05/29 10:00
PHST- 2002/05/29 10:00 [pubmed]
PHST- 2002/08/15 10:01 [medline]
PHST- 2002/05/29 10:00 [entrez]
AID - S0006899302025052 [pii]
AID - 10.1016/s0006-8993(02)02505-2 [doi]
PST - ppublish
SO  - Brain Res. 2002 Jun 21;941(1-2):34-42. doi: 10.1016/s0006-8993(02)02505-2.