PMID- 12031640
OWN - NLM
STAT- MEDLINE
DCOM- 20020621
LR  - 20191106
IS  - 0188-4409 (Print)
IS  - 0188-4409 (Linking)
VI  - 33
IP  - 3
DP  - 2002 May-Jun
TI  - Growth deficits in children with sickle cell disease.
PG  - 308-12
AB  - BACKGROUND: Growth deficits are common in children with sickle cell disease. Few 
      prospective studies are available and the pathophysiologic basis for the impaired 
      growth is not clearly understood. Our objectives were to collect data on 
      anthropomorphic measurements of children with sickle cell disease prospectively 
      followed for 1 year and to correlate them with hematologic data. METHODS: One 
      hundred children <8 years of age (73 with homozygous SS sickle cell anemia [HbSS] 
      and 27 with hemoglobinopathy SC [HbSC]) were included. Standardized Z scores of 
      weight for age (waz), height for age (haz), and weight for height (whz) were 
      compared to the National Center for Health Statistics (NCHS) reference 
      population. RESULTS: At study entry, the means (standard deviation [SD]) of waz, 
      haz, and whz were -0.69 (1.06), -0.65 (1.11), and -0.32 (1.00), respectively. 
      After 1 year of study, children with HbSS presented a significant decrease in waz 
      (p = 0.01) and whz (p = 0.02); the decrease in haz was not statistically 
      significant (p = 0.48). The effect was similar for children older or younger than 
      24 months of age. The decrease in waz and whz was significant for boys but not 
      for girls. After 1 year of follow-up, lower mean waz scores were observed among 
      patients with lower hemoglobin concentration and higher reticulocyte count (p = 
      0.03 and p = 0.08). Hemoglobin concentration was higher in girls. The 
      anthropomorphic measurements did not deteriorate significantly in children with 
      HbSC. CONCLUSIONS: Growth deficits may be demonstrable in children with HbSS, 
      even during a short period of observation. Fast red blood cell turnover may be 
      partially responsible for the observed effect.
FAU - Silva, Celia Maria
AU  - Silva CM
AD  - Hemoglobinopathy Out-Patient Clinic, Hemominas Foundation, Belo Horizonte, 
      Brazil.
FAU - Viana, Marcos Borato
AU  - Viana MB
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Arch Med Res
JT  - Archives of medical research
JID - 9312706
SB  - IM
MH  - Anemia, Sickle Cell/*physiopathology
MH  - *Anthropometry
MH  - Child
MH  - *Child Development
MH  - Humans
EDAT- 2002/05/29 10:00
MHDA- 2002/06/22 10:01
CRDT- 2002/05/29 10:00
PHST- 2002/05/29 10:00 [pubmed]
PHST- 2002/06/22 10:01 [medline]
PHST- 2002/05/29 10:00 [entrez]
AID - S0188-4409(01)00360-5 [pii]
AID - 10.1016/s0188-4409(01)00360-5 [doi]
PST - ppublish
SO  - Arch Med Res. 2002 May-Jun;33(3):308-12. doi: 10.1016/s0188-4409(01)00360-5.