PMID- 1203171
OWN - NLM
STAT- MEDLINE
DCOM- 19760318
LR  - 20181113
IS  - 0007-1021 (Print)
IS  - 0007-1021 (Linking)
VI  - 56
IP  - 1
DP  - 1975 Feb
TI  - The induction of renal papillary necrosis in Gunn rats by analgesics and 
      analgesic mixtures.
PG  - 92-7
AB  - Homozygous members of the mutant Gunn strain of Wistar rats genetically lack the 
      enzyme uridine diphosphate glucuronyl transferase. "High" and "low" dose gavage 
      feeding for 18-34 days of an analgesic mixture containing aspirin, phenacetin and 
      caffeine (APC) confirmed the previously reported susceptibility of these animals 
      to analgesic induced renal papillary necrosis. Heterozygotes do not share the 
      gross enzyme deficiency of homozygotes and, when treated with APC under identical 
      conditions, failed to develop renal papillary necrosis. Groups of homozygotes 
      were dosed by gavage with aspirin, phenacetin and paracetamol for 4 weeks. Renal 
      papillary necrosis was produced by all 3 drugs, the lowest frequency of lesions 
      occurring with phenacetin. It is postulated that the enzyme deficiency of 
      homozygous Gunn rats influences the metabolism of analgesics to favour the 
      excretion of nephrotoxic metabolites. The renal papillary necrosis appearing in 
      these experiments is essentially an acute lesion, differing both in natural 
      history and morphology from the renal papillary necrosis of analgesic 
      nephropathy, suggesting that the pathogeneses of the experimental and human 
      lesions differ.
FAU - Axelsen, R A
AU  - Axelsen RA
LA  - eng
PT  - Journal Article
PL  - England
TA  - Br J Exp Pathol
JT  - British journal of experimental pathology
JID - 0372543
RN  - 0 (Analgesics)
RN  - 362O9ITL9D (Acetaminophen)
RN  - 3G6A5W338E (Caffeine)
RN  - ER0CTH01H9 (Phenacetin)
RN  - R16CO5Y76E (Aspirin)
SB  - IM
MH  - Acetaminophen/toxicity
MH  - Analgesics/*toxicity
MH  - Animals
MH  - Aspirin/toxicity
MH  - Caffeine/toxicity
MH  - Female
MH  - Heterozygote
MH  - Homozygote
MH  - Kidney Papillary Necrosis/*chemically induced/pathology
MH  - Male
MH  - Phenacetin/toxicity
MH  - Rats
MH  - Rats, Inbred Strains
PMC - PMC2072714
EDAT- 1975/02/01 00:00
MHDA- 1975/02/01 00:01
PMCR- 1975/02/01
CRDT- 1975/02/01 00:00
PHST- 1975/02/01 00:00 [pubmed]
PHST- 1975/02/01 00:01 [medline]
PHST- 1975/02/01 00:00 [entrez]
PHST- 1975/02/01 00:00 [pmc-release]
PST - ppublish
SO  - Br J Exp Pathol. 1975 Feb;56(1):92-7.