PMID- 12031853
OWN - NLM
STAT- MEDLINE
DCOM- 20020904
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 942
IP  - 1-2
DP  - 2002 Jun 28
TI  - Intracerebroventricular choline increases plasma vasopressin and augments plasma 
      vasopressin response to osmotic stimulation and hemorrhage.
PG  - 58-70
AB  - Intracerebroventricular (i.c.v.) injection of choline (50-150 microg), a 
      precursor of the neurotransmitter acetylcholine, produced a time-and 
      dose-dependent increase in plasma vasopressin levels in conscious, freely moving 
      rats. The increase in plasma vasopressin in response to i.c.v. choline (150 
      microg) was inhibited by pretreatment with the nicotinic receptor antagonist, 
      mecamylamine (50 microg; i.c.v.), but not by the muscarinic receptor antagonist, 
      atropine (10 microg; i.c.v). The choline-induced rise in plasma vasopressin 
      levels was greatly attenuated by hemicholinium-3 (HC-3; 20 microg; i.c.v.), a 
      neuronal choline uptake inhibitor. Choline (50 or 150 microg; i.c.v.) produced a 
      much greater increase in plasma vasopressin levels in osmotically stimulated or 
      hemorrhaged rats than in normal rats. Choline (150 microg; i.c.v.) also enhanced 
      plasma vasopressin response to graded hemorrhage; the enhancing effect of choline 
      was also attenuated by HC-3 (20 microg; i.c.v.). Choline and acetylcholine 
      concentrations in hypothalamic dialysates increased significantly following 
      i.c.v. injection of choline (150 microg). It is concluded that choline increases 
      plasma vasopressin levels by stimulating central nicotinic receptors indirectly, 
      through the enhancement of acetylcholine synthesis and release, and augments the 
      ability of osmotic stimulations or hemorrhage to stimulate vasopressin release.
FAU - Savci, Vahide
AU  - Savci V
AD  - Department of Pharmacology and Clinical Pharmacology, Uludag University Medical 
      School, Bursa, Turkey.
FAU - Goktalay, Gokhan
AU  - Goktalay G
FAU - Ulus, Ismail H
AU  - Ulus IH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Muscarinic Antagonists)
RN  - 0 (Neurotransmitter Uptake Inhibitors)
RN  - 0 (Nicotinic Antagonists)
RN  - 0 (Receptors, Nicotinic)
RN  - 0 (Saline Solution, Hypertonic)
RN  - 11000-17-2 (Vasopressins)
RN  - 312-45-8 (Hemicholinium 3)
RN  - N91BDP6H0X (Choline)
RN  - N9YNS0M02X (Acetylcholine)
SB  - IM
MH  - Acetylcholine/*biosynthesis
MH  - Animals
MH  - Choline/*metabolism/pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Hemicholinium 3/pharmacology
MH  - Hemorrhage/drug therapy/metabolism/physiopathology
MH  - Hypothalamus/drug effects/*metabolism
MH  - Injections, Intraventricular
MH  - Male
MH  - Muscarinic Antagonists/pharmacology
MH  - Neurotransmitter Uptake Inhibitors/pharmacology
MH  - Nicotinic Antagonists/pharmacology
MH  - Presynaptic Terminals/drug effects/*metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Receptors, Nicotinic/drug effects/*metabolism
MH  - Saline Solution, Hypertonic/pharmacology
MH  - Synaptic Transmission/drug effects/*physiology
MH  - Vasopressins/blood/*metabolism
MH  - Water-Electrolyte Balance/drug effects/physiology
EDAT- 2002/05/29 10:00
MHDA- 2002/09/06 10:01
CRDT- 2002/05/29 10:00
PHST- 2002/05/29 10:00 [pubmed]
PHST- 2002/09/06 10:01 [medline]
PHST- 2002/05/29 10:00 [entrez]
AID - S0006899302026926 [pii]
AID - 10.1016/s0006-8993(02)02692-6 [doi]
PST - ppublish
SO  - Brain Res. 2002 Jun 28;942(1-2):58-70. doi: 10.1016/s0006-8993(02)02692-6.