PMID- 12032526
OWN - NLM
STAT- MEDLINE
DCOM- 20020704
LR  - 20220408
IS  - 0022-3476 (Print)
IS  - 0022-3476 (Linking)
VI  - 140
IP  - 5
DP  - 2002 May
TI  - Atopy, asthma, and antibodies to Ascaris among rural and urban children in Kenya.
PG  - 582-8
AB  - OBJECTIVE: The purpose of this study was to evaluate differences in the 
      relationship between asthma and immune responses to allergens in children living 
      in rural and urban areas of Kenya. STUDY DESIGN: Children (mean age, 11 years) 
      from Kabati (n = 136), a rural village, and Thika (n = 129), a small town, were 
      studied by skin testing and serum immunoglobulin E (IgE) and immunoglobulin G 
      (IgG) antibody measurement. Asthma was evaluated by symptoms, as well as 
      spirometry before and after vigorous exercise to test for exercised-induced 
      bronchospasm (EIB). School children from a study performed in Atlanta, Georgia, 
      were used for comparison of anthropometric and immunologic results. RESULTS: 
      Compared with the urban area of Kenya, children living in the rural area had a 
      lower percentage of body fat, smaller and fewer skin test responses to allergens, 
      a higher prevalence of IgE antibodies to Ascaris (67% vs 26%) and 10-fold higher 
      total IgE. In the urban area of Kenya, there was a strong correlation between EIB 
      and atopy determined both by IgE antibodies (P =.02) and skin tests (P =.002). By 
      contrast, in the rural area, none of the 13 children with EIB were skin-test 
      positive (vs 13/109 of children without EIB). CONCLUSIONS: Among the rural 
      children, there was no association between immune responses to allergens and 
      airway-related symptoms or reactivity. The association between asthma and atopy 
      seen in the town of Thika may represent an important step in the increase in 
      asthma seen both in urban Africa and in the West.
FAU - Perzanowski, Matthew S
AU  - Perzanowski MS
AD  - University of Virginia Asthma and Allergic Diseases Center, Health Sciences 
      Center, Charlottesville, 22908-1355, USA.
FAU - Ng'ang'a, Lucy W
AU  - Ng'ang'a LW
FAU - Carter, Melody C
AU  - Carter MC
FAU - Odhiambo, Joseph
AU  - Odhiambo J
FAU - Ngari, Peter
AU  - Ngari P
FAU - Vaughan, John W
AU  - Vaughan JW
FAU - Chapman, Martin D
AU  - Chapman MD
FAU - Kennedy, Malcolm W
AU  - Kennedy MW
FAU - Platts-Mills, Thomas A E
AU  - Platts-Mills TA
LA  - eng
GR  - AI-20565/AI/NIAID NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Pediatr
JT  - The Journal of pediatrics
JID - 0375410
RN  - 0 (Antibodies, Helminth)
SB  - IM
CIN - J Pediatr. 2003 Apr;142(4):450; author reply 450-1. PMID: 12712068
MH  - Adolescent
MH  - Animals
MH  - Anthropometry
MH  - Antibodies, Helminth/*blood
MH  - Ascaris/*immunology
MH  - Asthma/epidemiology/*immunology/*parasitology
MH  - Case-Control Studies
MH  - Child
MH  - Humans
MH  - Hypersensitivity, Immediate/*epidemiology
MH  - Kenya/epidemiology
MH  - Logistic Models
MH  - Prevalence
MH  - Respiratory Mechanics
MH  - Rural Population
MH  - Statistics, Nonparametric
MH  - Urban Population
EDAT- 2002/05/29 10:00
MHDA- 2002/07/05 10:01
CRDT- 2002/05/29 10:00
PHST- 2002/05/29 10:00 [pubmed]
PHST- 2002/07/05 10:01 [medline]
PHST- 2002/05/29 10:00 [entrez]
AID - S0022-3476(02)03469-8 [pii]
AID - 10.1067/mpd.2002.122937 [doi]
PST - ppublish
SO  - J Pediatr. 2002 May;140(5):582-8. doi: 10.1067/mpd.2002.122937.