PMID- 12032590
OWN - NLM
STAT- MEDLINE
DCOM- 20020722
LR  - 20061115
IS  - 1434-5161 (Print)
IS  - 1434-5161 (Linking)
VI  - 47
IP  - 5
DP  - 2002
TI  - Allelic structures at hypervariable minisatellite B6.7 in Japanese show 
      population specificity.
PG  - 232-8
AB  - Human minisatellite B6.7 shows extensive allele length and structural variability 
      in north Europeans. We analysed this locus in the Japanese population. Allele 
      size distributions showed that Japanese retain extensive allele length 
      variability but have significantly smaller alleles compared with north Europeans. 
      In contrast, there is very little variation in flanking DNA, with only one 
      single-nucleotide polymorphism (SNP) near the minisatellite. Ninety-two Japanese 
      alleles were further characterised by minisatellite variant repeat mapping by 
      polymerase chain reaction (MVR-PCR). These alleles showed a wide variety of 
      internal MVR structures, despite their relative shortness, with most alleles 
      observed only once in the sample. The true heterozygosity is estimated at 99.95%, 
      with well in excess of 2000 different alleles existing in the Japanese 
      population. Dot matrix analysis showed that groups of related alleles sharing 
      structural motifs could be identified within Japanese and in north Europeans, and 
      that these groups are population specific with no examples of significant 
      similarity between any Japanese and north European alleles. Minisatellite B6.7 
      therefore shows huge allele variability and fast repeat turnover in Japanese as 
      well as north European populations, and provides novel lineage markers for 
      exploring very recent events in human population history.
FAU - Mizukoshi, Tsunenori
AU  - Mizukoshi T
AD  - Department of Legal Medicine, Sapporo Medical University School of Medicine, 
      South 1 West 17, Chuo-ku, Sapporo 060-8556, Japan. tm13@pop01.odn.ne.jp
FAU - Tamaki, Keiji
AU  - Tamaki K
FAU - Azumi, Jun-ichi
AU  - Azumi J
FAU - Matsumoto, Hiroshi
AU  - Matsumoto H
FAU - Imai, Kohzoh
AU  - Imai K
FAU - Jeffreys, Alec J
AU  - Jeffreys AJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Hum Genet
JT  - Journal of human genetics
JID - 9808008
RN  - 0 (DNA Primers)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Alleles
MH  - Amino Acid Sequence
MH  - Chromosome Mapping
MH  - DNA/metabolism
MH  - DNA Primers/chemistry
MH  - Haplotypes
MH  - Humans
MH  - Japan
MH  - Minisatellite Repeats/*genetics
MH  - Molecular Sequence Data
MH  - Polymerase Chain Reaction
MH  - Repetitive Sequences, Nucleic Acid/*genetics
MH  - Sensitivity and Specificity
MH  - Sequence Homology, Amino Acid
EDAT- 2002/05/29 10:00
MHDA- 2002/07/23 10:01
CRDT- 2002/05/29 10:00
PHST- 2002/05/29 10:00 [pubmed]
PHST- 2002/07/23 10:01 [medline]
PHST- 2002/05/29 10:00 [entrez]
AID - 10.1007/s100380200031 [doi]
PST - ppublish
SO  - J Hum Genet. 2002;47(5):232-8. doi: 10.1007/s100380200031.