PMID- 12034528
OWN - NLM
STAT- MEDLINE
DCOM- 20020614
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 134
IP  - 2
DP  - 2002 Apr 15
TI  - Chromosome 16 inversion-associated translocations in acute myeloid leukemia 
      elucidated using a dual-color CBFB DNA probe.
PG  - 142-4
AB  - We describe two cases of acute myelomonocytic leukemia with eosinophilia 
      (AML-M4Eo) that were diagnosed with an inv(16)(p13q22) based on conventional 
      cytogenetics (CC) and fluorescence in situ hybridization (FISH) technique using a 
      chromosome 16p arm specific paint probe. Additional FISH analysis with a 
      dual-color CBFB DNA probe showed that the 3' portion of the CBFB gene was 
      translocated to chromosome 10p13 in the first patient and 1p36 in the other. 
      These two cases indicate that some inv(16)(p13q22) identified by CC and FISH with 
      chromosome arm-specific painting probe may represent cases of 
      inversion-associated translocation. We suggest that all cases with 
      inv(16)(p13q22) should be investigated by FISH with appropriate probes for a 
      possible translocation of 16q22-->qter to another chromosome.
FAU - Aventin, Anna
AU  - Aventin A
AD  - Department of Hematology, University Hospital Sant Pau, Barcelona, Spain. 
      aaventin@hsp.santpau.es
FAU - Espadaler, Montserrat
AU  - Espadaler M
FAU - Casas, Silvia
AU  - Casas S
FAU - Duarte, Jose
AU  - Duarte J
FAU - Nomdedeu, Josep
AU  - Nomdedeu J
FAU - Sierra, Jorge
AU  - Sierra J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (CBFB protein, human)
RN  - 0 (Core Binding Factor beta Subunit)
RN  - 0 (DNA Probes)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Transcription Factor AP-2)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Adult
MH  - *Chromosome Inversion
MH  - Chromosomes, Human, Pair 16/*genetics
MH  - Color
MH  - Core Binding Factor beta Subunit
MH  - DNA Probes/genetics/metabolism
MH  - DNA-Binding Proteins/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/*methods
MH  - Karyotyping
MH  - Leukemia, Myeloid, Acute/*genetics
MH  - Male
MH  - Middle Aged
MH  - Transcription Factor AP-2
MH  - Transcription Factors/*genetics
MH  - Translocation, Genetic/*genetics
EDAT- 2002/05/30 10:00
MHDA- 2002/06/18 10:01
CRDT- 2002/05/30 10:00
PHST- 2002/05/30 10:00 [pubmed]
PHST- 2002/06/18 10:01 [medline]
PHST- 2002/05/30 10:00 [entrez]
AID - S0165460801006161 [pii]
AID - 10.1016/s0165-4608(01)00616-1 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2002 Apr 15;134(2):142-4. doi: 
      10.1016/s0165-4608(01)00616-1.