PMID- 12037743
OWN - NLM
STAT- MEDLINE
DCOM- 20021218
LR  - 20190710
IS  - 1531-5037 (Electronic)
IS  - 0022-3468 (Linking)
VI  - 37
IP  - 6
DP  - 2002 Jun
TI  - Cytogenetic and histologic findings in Wilms' tumor.
PG  - 823-7
AB  - PURPOSE: The cytogenetic abnormalities occurring in Wilms' tumors diagnosed and 
      treated at the authors' institution were reviewed. Correlation with tumor 
      histopathology, stage, and outcome were evaluated. METHODS: Sixty-seven Wilms' 
      tumors were encountered between 1984 and 1997. Tissue culture was obtained in 63 
      (94%) cases. Charts were reviewed retrospectively to obtain tumor histopathology, 
      stage, and outcome. RESULTS: All tumors were examined in accordance with the 
      National Wilms' Tumor Study (NWTS). Sixty-one were unilateral (54 unicentric, 7 
      multicentric), and 6 were bilateral (2 multicentric). Five Wilms' tumors showed 
      anaplasia, whereas 62 showed favorable histology. Twenty children were stage I, 
      17 stage II, 20 stage III, 4 stage IV, and 6 stage V. Forty-eight (72%) tumors 
      showed an abnormal karyotype. Chromosomal gain was more common than chromosomal 
      loss, because hyperdiploidy was seen in 30 cases and hypodiploidy in 4. The most 
      common aneuploidies were gains of chromosomes 6, 7, 8, 12, 13, and 18. In 
      general, there was no correlation between specific chromosomal abnormalities with 
      either tumor stage or histologic subtype. The only exceptions were anaplastic 
      changes that were associated with poor prognosis and showed a variety of 
      chromosomal changes including hyperdiploidy, hypodiploidy, and structural 
      rearrangements. The 3 tumors causing mortality exhibited tetraploidy, 
      hypodiploidy, and diploidy with a t(1p:11q) karyotype, respectively. Clonal 
      progression was identified in Wilms' tumors when compared with its accompanying 
      nephrogenic rest. A normal karyotype was seen more commonly in younger patients. 
      CONCLUSIONS: Wilms' tumors display a variety of chromosomal abnormalities. These 
      are particularly seen in anaplastic tumors and are less likely seen in younger 
      patients. Overall, chromosomal gain was more common than loss with trisomies of 
      chromosomes 12, 8, and 6 being the most frequently seen.
CI  - Copyright 2002, Elsevier Science (USA). All rights reserved.
FAU - Gow, Kenneth W
AU  - Gow KW
AD  - Department of Surgery, the University of British Columbia and the British 
      Columbia's Children's Hospital, Vancouver, British Columbia, Canada.
FAU - Murphy, James J
AU  - Murphy JJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Pediatr Surg
JT  - Journal of pediatric surgery
JID - 0052631
SB  - IM
MH  - Child
MH  - Chromosome Aberrations/*classification
MH  - Cytogenetics
MH  - Disease Progression
MH  - Female
MH  - Fetal Diseases/genetics/pathology
MH  - Humans
MH  - Karyotyping
MH  - Male
MH  - Neoplasm Staging
MH  - Ploidies
MH  - Retrospective Studies
MH  - Wilms Tumor/*genetics/*pathology
EDAT- 2002/05/31 10:00
MHDA- 2002/12/19 04:00
CRDT- 2002/05/31 10:00
PHST- 2002/05/31 10:00 [pubmed]
PHST- 2002/12/19 04:00 [medline]
PHST- 2002/05/31 10:00 [entrez]
AID - S0022346802603306 [pii]
AID - 10.1053/jpsu.2002.32880 [doi]
PST - ppublish
SO  - J Pediatr Surg. 2002 Jun;37(6):823-7. doi: 10.1053/jpsu.2002.32880.