PMID- 12039408
OWN - NLM
STAT- MEDLINE
DCOM- 20021114
LR  - 20190906
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 63
IP  - 4
DP  - 2002 Apr
TI  - Relevance of KIR gene polymorphisms in bone marrow transplantation outcome.
PG  - 271-80
AB  - Natural Killer (NK) cells may be involved both in allogeneic bone marrow 
      transplantation (BMT) rejection and graft-versus-host disease (GVHD). The 
      physiologic functions of NK cells appear to be regulated by diverse 
      non-inhibitory and inhibitory receptors including the killer cell 
      immunoglobulin-like receptors (KIR). Although human leukocyte antigen (HLA) 
      epitope mismatches are well-known causes of NK alloreactivity, the role of KIR 
      genes in transplantation remains to be further investigated. In this study, we 
      have evaluated whether KIR genotype differences between donors and recipients of 
      HLA identical (related and unrelated) compared with HLA non-identical unrelated 
      BMT, had an impact on transplantation outcome. Our results show that 5 of 15 KIR 
      genes were always identical in donors and recipients and most variations were 
      observed in the number and specificity of noninhibitory KIR genes. Based on the 
      presence or absence of particular KIR genes, 70 different genotypes were obtained 
      from all individuals. According to the donor or recipient KIR genotype, different 
      combination patterns were described. Interestingly, when the recipient KIR 
      genotype was "included" in the donor KIR genotype, 100% (11/11 pairs) of 
      unrelated BMT developed GVHD compared with 60% (18/30) in all other combinations 
      (p = 0.012). In contrast, no GVHD was observed in related BMT when the recipient 
      KIR genotype was "included" in the donor KIR genotype (p = 0.0001). In 
      conclusion, our results reveal a great diversity for KIR genotypes in donors and 
      recipients of BMT and that the risk of GVHD was maximum in unrelated BMT when the 
      recipient KIR genotype was "included" in the donor KIR genotype.
FAU - Gagne, Katia
AU  - Gagne K
AD  - Laboratoire d'Histocompatibilite Immunogenetique, EFS Pays de la Loire, Nantes 
      Cedex, France.
FAU - Brizard, Geraldine
AU  - Brizard G
FAU - Gueglio, Brigitte
AU  - Gueglio B
FAU - Milpied, Noel
AU  - Milpied N
FAU - Herry, Patricia
AU  - Herry P
FAU - Bonneville, Francoise
AU  - Bonneville F
FAU - Cheneau, Mary Luce
AU  - Cheneau ML
FAU - Schleinitz, Nicolas
AU  - Schleinitz N
FAU - Cesbron, Anne
AU  - Cesbron A
FAU - Follea, Gilles
AU  - Follea G
FAU - Harrousseau, Jean Luc
AU  - Harrousseau JL
FAU - Bignon, Jean Denis
AU  - Bignon JD
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Receptors, Immunologic)
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Bone Marrow Transplantation
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Gene Frequency
MH  - Humans
MH  - Infant
MH  - *Killer Cells, Natural
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Genetic
MH  - Receptors, Immunologic/*genetics
MH  - Receptors, KIR
MH  - Treatment Outcome
EDAT- 2002/06/01 10:00
MHDA- 2002/11/26 04:00
CRDT- 2002/06/01 10:00
PHST- 2002/06/01 10:00 [pubmed]
PHST- 2002/11/26 04:00 [medline]
PHST- 2002/06/01 10:00 [entrez]
AID - S0198885902003737 [pii]
AID - 10.1016/s0198-8859(02)00373-7 [doi]
PST - ppublish
SO  - Hum Immunol. 2002 Apr;63(4):271-80. doi: 10.1016/s0198-8859(02)00373-7.