PMID- 12039525
OWN - NLM
STAT- MEDLINE
DCOM- 20021226
LR  - 20221207
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 63
IP  - 6
DP  - 2002 Jun
TI  - Exon 1 polymorphism of the B2BKR gene does not influence the clinical status of 
      patients with hereditary angioedema.
PG  - 492-4
AB  - Polymorphic variants of B2 receptors for bradykinin (B2BKR) have been postulated 
      to influence a clinical manifestation of hereditary angioedema. In this study, 
      exon 1 nonanucleotide deletion polymorphism in the B2BKR gene was examined in 37 
      patients with hereditary angioedema. The patients were grouped according to 
      disease severity or the age of the first clinical manifestation of disease. No 
      significant differences in allelic frequencies were found between particular 
      subgroups of patients. Therefore, we concluded that this polymorphism does not 
      seem to have any significant effect on the course and severity of hereditary 
      angioedema in Caucasians.
FAU - Freiberger, Tomas
AU  - Freiberger T
AD  - Department of Immunogenetics, Research Institute of Child Health, Brno, Czech 
      Republic. tomf@vuzd.cz
FAU - Vyskocilova, Martina
AU  - Vyskocilova M
FAU - Kolarova, Lenka
AU  - Kolarova L
FAU - Kuklinek, Pavel
AU  - Kuklinek P
FAU - Krystufkova, Olga
AU  - Krystufkova O
FAU - Lahodna, Marie
AU  - Lahodna M
FAU - Hanzlikova, Jana
AU  - Hanzlikova J
FAU - Litzman, Jiri
AU  - Litzman J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Receptor, Bradykinin B2)
RN  - 0 (Receptors, Bradykinin)
SB  - IM
MH  - Angioedema/*diagnosis/*genetics
MH  - Czech Republic
MH  - *Exons
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - Humans
MH  - Male
MH  - *Polymorphism, Genetic
MH  - Receptor, Bradykinin B2
MH  - Receptors, Bradykinin/*genetics
MH  - White People
EDAT- 2002/06/01 10:00
MHDA- 2002/12/27 04:00
CRDT- 2002/06/01 10:00
PHST- 2002/06/01 10:00 [pubmed]
PHST- 2002/12/27 04:00 [medline]
PHST- 2002/06/01 10:00 [entrez]
AID - S019888590200397X [pii]
AID - 10.1016/s0198-8859(02)00397-x [doi]
PST - ppublish
SO  - Hum Immunol. 2002 Jun;63(6):492-4. doi: 10.1016/s0198-8859(02)00397-x.