PMID- 12041731
OWN - NLM
STAT- MEDLINE
DCOM- 20030729
LR  - 20190922
IS  - 1566-5240 (Print)
IS  - 1566-5240 (Linking)
VI  - 2
IP  - 3
DP  - 2002 May
TI  - Current developments in human molecular cytogenetic techniques.
PG  - 283-97
AB  - In the last decade a variety of fluorescence in situ hybridization (FISH) assays 
      have been developed. In this paper we present an overview on the currently 
      available methods in molecular cytogenetics, highlighting their advantages and 
      limitations, as well as their applications. Even though one has to be impressed 
      by the total number of new techniques introduced in molecular cytogenetics, one 
      has to be aware of the fact that it is not the brilliance of a technique that is 
      important but the scientific question that can be addressed by it. In this review 
      special emphasis has given in describing possible strategies for the 
      characterization of marker and derivative chromosomes in tumor- and clinical 
      cytogenetics.
FAU - Liehr, Thomas
AU  - Liehr T
AD  - Institute of Human Genetics and Anthropology, Jena, Germany. 
      i8lith@mti-n.mti.uni-jena.de
FAU - Claussen, Uwe
AU  - Claussen U
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Netherlands
TA  - Curr Mol Med
JT  - Current molecular medicine
JID - 101093076
RN  - 0 (DNA Probes)
RN  - 0 (Fluorescent Dyes)
SB  - IM
MH  - Centromere/genetics
MH  - Chromosome Breakage
MH  - Chromosome Mapping
MH  - Chromosome Painting
MH  - Cytogenetic Analysis/*trends
MH  - DNA Probes
MH  - Fluorescent Dyes
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Oligonucleotide Array Sequence Analysis
MH  - Uniparental Disomy/genetics
RF  - 159
EDAT- 2002/06/04 10:00
MHDA- 2003/07/30 05:00
CRDT- 2002/06/04 10:00
PHST- 2002/06/04 10:00 [pubmed]
PHST- 2003/07/30 05:00 [medline]
PHST- 2002/06/04 10:00 [entrez]
AID - 10.2174/1566524024605725 [doi]
PST - ppublish
SO  - Curr Mol Med. 2002 May;2(3):283-97. doi: 10.2174/1566524024605725.