PMID- 12042010
OWN - NLM
STAT- MEDLINE
DCOM- 20020909
LR  - 20220330
IS  - 0195-668X (Print)
IS  - 0195-668X (Linking)
VI  - 23
IP  - 11
DP  - 2002 Jun
TI  - Prediction of outcome by neurohumoral activation, the six-minute walk test and 
      the Minnesota Living with Heart Failure Questionnaire in an outpatient cohort 
      with congestive heart failure.
PG  - 886-91
AB  - AIMS: To compare the precursor of atrial and brain natriuretic peptide (N-ANP, 
      N-BNP), brain natriuretic peptide (BNP), big endothelin-1, the 6-min walk test 
      and the Minnesota Living with Heart Failure Questionnaire (LHFQ) with regard to 
      short-term outcome in an ambulatory heart failure population. METHODS AND 
      RESULTS: Ninety-six individuals (left ventricular ejection fraction of 26+/-10%) 
      were included in the study. Within 1 day blood samples of N-ANP, N-BNP, BNP and 
      big endothelin-1 were obtained, and the 6-min walk test and LHFQ were measured. 
      The predictive power of these variables - including renin-angiotensin system 
      antagonist therapy - in respect of 1-year event-free survival were calculated 
      with a Cox regression analysis. All investigated variables had the power to 
      predict outcome in a univariate analysis. Multivariate analysis revealed that 
      N-ANP (chi-square=58 P<0.0001), BNP (chi-square=8 P<0.01), the LHFQ (chi-square=6 
      P<0.02) and the renin-angiotensin system antagonist (chi-square=4 P<0.05), are 
      independent predictors. CONCLUSION: We conclude that, in an open clinical cohort 
      of patients with large differences in the progression of the disease, N-ANP, BNP 
      and LHFQ are the most reliable predictors of worsening heart failure in the short 
      term. However, the dosage of the ACE inhibitor influenced short-term survival in 
      this population.
CI  - Copyright 2002 The European Society of Cardiology. Published by Elsevier Science 
      Ltd. All rights reserved.
FAU - Hulsmann, M
AU  - Hulsmann M
AD  - Department of Cardiology, University of Vienna, Vienna, Austria.
FAU - Berger, R
AU  - Berger R
FAU - Sturm, B
AU  - Sturm B
FAU - Bojic, A
AU  - Bojic A
FAU - Woloszczuk, W
AU  - Woloszczuk W
FAU - Bergler-Klein, J
AU  - Bergler-Klein J
FAU - Pacher, R
AU  - Pacher R
LA  - eng
PT  - Journal Article
PL  - England
TA  - Eur Heart J
JT  - European heart journal
JID - 8006263
RN  - 0 (Angiotensin-Converting Enzyme Inhibitors)
RN  - 0 (Endothelin-1)
RN  - 0 (Endothelins)
RN  - 0 (Protein Precursors)
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - 85637-73-6 (Atrial Natriuretic Factor)
SB  - IM
MH  - Activities of Daily Living
MH  - Angiotensin-Converting Enzyme Inhibitors/therapeutic use
MH  - Atrial Natriuretic Factor/metabolism
MH  - Cohort Studies
MH  - Endothelin-1
MH  - Endothelins/metabolism
MH  - Female
MH  - Heart Failure/diagnosis/*epidemiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Natriuretic Peptide, Brain/metabolism
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - Protein Precursors/metabolism
MH  - Surveys and Questionnaires
MH  - Walking
EDAT- 2002/06/04 10:00
MHDA- 2002/09/11 10:01
CRDT- 2002/06/04 10:00
PHST- 2002/06/04 10:00 [pubmed]
PHST- 2002/09/11 10:01 [medline]
PHST- 2002/06/04 10:00 [entrez]
AID - S0195668X0193115X [pii]
AID - 10.1053/euhj.2001.3115 [doi]
PST - ppublish
SO  - Eur Heart J. 2002 Jun;23(11):886-91. doi: 10.1053/euhj.2001.3115.