PMID- 12043153
OWN - NLM
STAT- MEDLINE
DCOM- 20020627
LR  - 20201208
IS  - 0372-9311 (Print)
IS  - 0372-9311 (Linking)
IP  - 2
DP  - 2002 Mar-Apr
TI  - [Cholera toxin as Vibrio cholera superantigen].
PG  - 50-5
AB  - Experimental data confirming our earlier suggestion, that cholerae toxin (CT) 
      possesses superantigen (SA) properties are presented. When used in very small 
      doses, CT has been found to induce polyclonal activation of T lymphocytes, 
      essentially exceeding that observed in classical T mitogens characteristic of SA. 
      CT, in contrast to mitogens and similarly to other SA, is shown to display this 
      activity only in the presence of antigen-presenting cells. Experiments with the 
      use of monoclonal antibodies to the variable region of the beta-chain of the 
      T-cell receptor (V beta TCR) have demonstrated that CT, similarly to other SA, 
      are capable of inducing expression of certain types of V beta TCR and causing 
      polyclonal activation of T lymphocytes carrying these types of V beta TCR. The 
      presence of these properties gives grounds for regarding CT as SA. The SA 
      activity of CT has been found to be linked with its subunit A.
FAU - Vasil'eva, G I
AU  - Vasil'eva GI
AD  - Research Institute for Plague Control, Rostov-on-Don, Russia.
FAU - Kozlovskii, V N
AU  - Kozlovskii VN
FAU - Mishan'kin, B N
AU  - Mishan'kin BN
FAU - Mishan'kin, M B
AU  - Mishan'kin MB
LA  - rus
PT  - Comparative Study
PT  - Journal Article
TT  - Kholernyi toksin--superantigen Vibrio cholerae.
PL  - Russia (Federation)
TA  - Zh Mikrobiol Epidemiol Immunobiol
JT  - Zhurnal mikrobiologii, epidemiologii i immunobiologii
JID - 0415217
RN  - 0 (Immunoglobulin Variable Region)
RN  - 0 (Superantigens)
RN  - 9012-63-9 (Cholera Toxin)
SB  - IM
MH  - Animals
MH  - Antigen-Presenting Cells/drug effects
MH  - Cells, Cultured
MH  - Cholera Toxin/*immunology/pharmacology
MH  - Immunoglobulin Variable Region/immunology
MH  - Lymphocyte Activation/drug effects
MH  - Mice
MH  - Spleen/immunology
MH  - Superantigens/*immunology
MH  - T-Lymphocyte Subsets/drug effects/immunology
MH  - Vibrio cholerae/*immunology
EDAT- 2002/06/05 10:00
MHDA- 2002/06/28 10:01
CRDT- 2002/06/05 10:00
PHST- 2002/06/05 10:00 [pubmed]
PHST- 2002/06/28 10:01 [medline]
PHST- 2002/06/05 10:00 [entrez]
PST - ppublish
SO  - Zh Mikrobiol Epidemiol Immunobiol. 2002 Mar-Apr;(2):50-5.