PMID- 12043851
OWN - NLM
STAT- MEDLINE
DCOM- 20020702
LR  - 20190922
IS  - 0277-0903 (Print)
IS  - 0277-0903 (Linking)
VI  - 39
IP  - 3
DP  - 2002 May
TI  - Once-daily administration of budesonide Turbuhaler was as effective as 
      twice-daily treatment in patients with mild to moderate persistent asthma.
PG  - 203-10
AB  - In a double-blind, randomized, placebo-controlled trial, 288 patients with mild 
      to moderate persistent asthma currently on inhaled glucocorticosteroids (GCSs) 
      were treated with budesonide Turbuhaler, 200 microg once every night (q.n.), 100 
      microg twice-daily (b.i.d.), or placebo b.i.d. After 12 weeks, morning peak 
      expiratory flow (PEF) increased in both groups treated with budesonide but 
      decreased in placebo-treated patients. Symptom scores and bronchodilator use were 
      significantly reduced in both groups receiving active treatment (p = 
      0.023-0.0001) compared with patients treated with placebo. There was no 
      significant difference in outcome measurements between the two budesonide 
      regimens. Thus, patients with mild to moderate persistent asthma receiving b.i.d. 
      treatment with inhaled GCSs can usually be switched to budesonide Turbuhaler, 200 
      microg, q.n. without loss of asthma control.
FAU - Mintz, Sheldon
AU  - Mintz S
AD  - School of Medicine, University of Toronto and Respiratory Diseases Division, 
      Women's College Hospital, Sunnybrook, Ontario, Canada.
FAU - Alexander, Michael
AU  - Alexander M
FAU - Li, John H S
AU  - Li JH
FAU - Mayer, Perry V
AU  - Mayer PV
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Asthma
JT  - The Journal of asthma : official journal of the Association for the Care of 
      Asthma
JID - 8106454
RN  - 0 (Bronchodilator Agents)
RN  - 51333-22-3 (Budesonide)
SB  - IM
MH  - Administration, Inhalation
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Asthma/*drug therapy
MH  - Bronchodilator Agents/*administration & dosage
MH  - Budesonide/*administration & dosage
MH  - Double-Blind Method
MH  - Drug Administration Schedule
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nebulizers and Vaporizers
MH  - Severity of Illness Index
EDAT- 2002/06/05 10:00
MHDA- 2002/07/03 10:01
CRDT- 2002/06/05 10:00
PHST- 2002/06/05 10:00 [pubmed]
PHST- 2002/07/03 10:01 [medline]
PHST- 2002/06/05 10:00 [entrez]
AID - 10.1081/jas-120002469 [doi]
PST - ppublish
SO  - J Asthma. 2002 May;39(3):203-10. doi: 10.1081/jas-120002469.