PMID- 12045011
OWN - NLM
STAT- MEDLINE
DCOM- 20020712
LR  - 20210724
IS  - 1093-9946 (Print)
IS  - 1093-4715 (Linking)
VI  - 7
DP  - 2002 Jun 1
TI  - Animal models of ultraviolet radiation (UVR)-induced cutaneous melanoma.
PG  - d1531-4
AB  - The incidence of cutaneous melanoma continues to increase in many parts of the 
      world including the United States. The American Cancer Society predicts that 
      there will be approximately 53,600 new cases of melanoma in the United States 
      during 2002 and that there will be 7,400 deaths from melanoma during the same 
      time period. Increased understanding of the underlying mechanisms and risk 
      factors involved in the induction of this deadly disease will require the use of 
      suitable animal models of melanoma. To date, the induction of cutaneous melanoma 
      with ultraviolet radiation (UVR) alone has been observed only in a few diverse 
      animal models: a South American opossum, Monodelphis domestica; a hybrid fish, 
      Xiphophorus; several stocks of transgenic mice; and in Angora goats. Most of 
      these models are not completely suitable due to: 1) the target cell for melanoma 
      formation; 2) the location of the melanocytes in the skin (i.e.- dermal as 
      opposed to epidermal in humans); or 3) problems associated with husbandry and 
      experimental manipulation. Recent studies have identified a mouse, the hepatocyte 
      growth factor/scatter factor (HGF/SF) transgenic mouse, as an attractive model 
      with which to study the induction of melanoma following a single, neonatal 
      exposure to a moderate dose of UVR.
FAU - Ley, Ronald D
AU  - Ley RD
AD  - Department of Cell Biology and Physiology and the Cancer Research and Treatment 
      Center, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, 
      USA. rley@unm.edu
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20020601
PL  - United States
TA  - Front Biosci
JT  - Frontiers in bioscience : a journal and virtual library
JID - 9709506
SB  - IM
MH  - Animals
MH  - *Disease Models, Animal
MH  - Humans
MH  - Melanoma/epidemiology/*etiology
MH  - Neoplasms, Radiation-Induced/epidemiology/*etiology
MH  - Skin Neoplasms/epidemiology/*etiology
MH  - Ultraviolet Rays/*adverse effects
RF  - 33
EDAT- 2002/06/05 10:00
MHDA- 2002/07/13 10:01
CRDT- 2002/06/05 10:00
PHST- 2002/06/05 10:00 [pubmed]
PHST- 2002/07/13 10:01 [medline]
PHST- 2002/06/05 10:00 [entrez]
AID - 10.2741/A857 [doi]
PST - epublish
SO  - Front Biosci. 2002 Jun 1;7:d1531-4. doi: 10.2741/A857.