PMID- 12048901
OWN - NLM
STAT- MEDLINE
DCOM- 20020621
LR  - 20181130
IS  - 0914-5087 (Print)
IS  - 0914-5087 (Linking)
VI  - 39
IP  - 5
DP  - 2002 May
TI  - Effects of carvedilol on plasma levels of interleukin-6 and tumor necrosis 
      factor-alpha in nine patients with dilated cardiomyopathy.
PG  - 253-7
AB  - OBJECTIVES: Whether beta-blocker therapy changes the circulating levels of 
      cytokines as congestive heart failure improves remains uncertain. METHODS: Nine 
      patients with idiopathic dilated cardiomyopathy, who had previously received 
      conventional treatment and were classified as New York Heart Association (NYHA) 
      functional class II, received carvedilol by stepwise dose increase up to 20 mg 
      daily, and the plasma interleukin-6 (IL-6) and tumor necrosis factor-alpha 
      (TNF-alpha) levels were measured. RESULTS: IL-6 was significantly reduced from 
      0.80 +/- 0.49 pg/ml before therapy to 0.21 +/- 0.08 pg/ml after carvedilol was 
      increased to 20 mg daily (p < 0.05). Moreover, IL-6 level had already decreased 
      significantly compared to the baseline when the dose of carvedilol had reached 10 
      mg daily (0.28 +/- 0.12 pg/ml, p < 0.05). TNF-alpha levels did not change 
      significantly. CONCLUSIONS: These results demonstrate that IL-6 concentration is 
      significantly decreased by beta-blocker therapy. The efficacy for heart failure 
      may be related to the change of IL-6 concentration.
FAU - Matsumura, Takayoshi
AU  - Matsumura T
AD  - Department of Cardiology, Sakakibara Heart Institute, Yoyogi 2-5-4, Shibuya-ku, 
      Tokyo 151-0053.
FAU - Tsushima, Kensuke
AU  - Tsushima K
FAU - Ohtaki, Eiji
AU  - Ohtaki E
FAU - Misu, Kazuhiko
AU  - Misu K
FAU - Tohbaru, Tetsuya
AU  - Tohbaru T
FAU - Asano, Ryuta
AU  - Asano R
FAU - Nagayama, Masatoshi
AU  - Nagayama M
FAU - Kitahara, Koichi
AU  - Kitahara K
FAU - Umemura, Jun
AU  - Umemura J
FAU - Sumiyoshi, Tetsuya
AU  - Sumiyoshi T
FAU - Hosoda, Saichi
AU  - Hosoda S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Cardiol
JT  - Journal of cardiology
JID - 8804703
RN  - 0 (Adrenergic beta-Antagonists)
RN  - 0 (Carbazoles)
RN  - 0 (Interleukin-6)
RN  - 0 (Propanolamines)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0K47UL67F2 (Carvedilol)
SB  - IM
MH  - Adrenergic beta-Antagonists/*therapeutic use
MH  - Carbazoles/*therapeutic use
MH  - Cardiomyopathy, Dilated/blood/*drug therapy/physiopathology
MH  - Carvedilol
MH  - Female
MH  - Humans
MH  - Interleukin-6/*blood
MH  - Male
MH  - Middle Aged
MH  - Propanolamines/*therapeutic use
MH  - Tumor Necrosis Factor-alpha/*metabolism
EDAT- 2002/06/07 10:00
MHDA- 2002/06/22 10:01
CRDT- 2002/06/07 10:00
PHST- 2002/06/07 10:00 [pubmed]
PHST- 2002/06/22 10:01 [medline]
PHST- 2002/06/07 10:00 [entrez]
PST - ppublish
SO  - J Cardiol. 2002 May;39(5):253-7.