PMID- 12049784
OWN - NLM
STAT- MEDLINE
DCOM- 20030127
LR  - 20211203
IS  - 0925-4773 (Print)
IS  - 0925-4773 (Linking)
VI  - 115
IP  - 1-2
DP  - 2002 Jul
TI  - Developmental and cell type-specific expression of the zinc finger transcription 
      factor Kruppel-like factor 4 (Klf4) in postnatal mouse testis.
PG  - 167-9
AB  - The transcription factor Kruppel-like factor 4 (Klf4, formerly gut-enriched 
      Kruppel-like factor, GKLF) is specifically expressed in postproliferative 
      epithelial cells such as those of the gut and the epidermis. The importance of 
      Klf4 in terminal differentiation of keratinocytes has been demonstrated by 
      targeted gene ablation in mice. Klf4-deficient mice fail to establish the barrier 
      function of the skin and die shortly after birth due to dehydration. Based on 
      these findings as well as in vitro studies, Klf4 was characterized as a 
      transcription factor essential for postproliferative differentiation of 
      epithelial cells. However, the testicular Klf4 expression pattern is completely 
      unknown. Here, we demonstrate that Klf4 is developmentally regulated during 
      postnatal testicular development of the mouse. Furthermore, we show strong 
      expression in the postmeiotic germ cells undergoing final differentiation into 
      sperm cells and provide evidence that Klf4 is also expressed in the somatic 
      Sertoli cells. These findings suggest that Klf4 might play an important role in 
      testicular differentiation in mammals.
FAU - Behr, Rudiger
AU  - Behr R
AD  - Department of Genetics, University of Pennsylvania Medical School, Philadelphia, 
      PA 19104, USA. ruediger.behr@uni-essen.de
FAU - Kaestner, Klaus H
AU  - Kaestner KH
LA  - eng
GR  - DK53839/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Ireland
TA  - Mech Dev
JT  - Mechanisms of development
JID - 9101218
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Klf4 protein, mouse)
RN  - 0 (Kruppel-Like Factor 4)
RN  - 0 (Kruppel-Like Transcription Factors)
RN  - 0 (RNA, Messenger)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Animals
MH  - DNA-Binding Proteins/*genetics
MH  - Gene Expression Profiling
MH  - *Gene Expression Regulation, Developmental
MH  - Kruppel-Like Factor 4
MH  - Kruppel-Like Transcription Factors
MH  - Male
MH  - Mice
MH  - RNA, Messenger
MH  - Seminiferous Tubules/metabolism
MH  - Sertoli Cells/metabolism
MH  - Spermatozoa/*metabolism
MH  - Testis/*metabolism
MH  - Transcription Factors/*genetics
MH  - Zinc Fingers/*genetics
EDAT- 2002/06/07 10:00
MHDA- 2003/01/28 04:00
CRDT- 2002/06/07 10:00
PHST- 2002/06/07 10:00 [pubmed]
PHST- 2003/01/28 04:00 [medline]
PHST- 2002/06/07 10:00 [entrez]
AID - S0925477302001272 [pii]
AID - 10.1016/s0925-4773(02)00127-2 [doi]
PST - ppublish
SO  - Mech Dev. 2002 Jul;115(1-2):167-9. doi: 10.1016/s0925-4773(02)00127-2.