PMID- 12050221
OWN - NLM
STAT- MEDLINE
DCOM- 20020703
LR  - 20061115
IS  - 0021-972X (Print)
IS  - 0021-972X (Linking)
VI  - 87
IP  - 6
DP  - 2002 Jun
TI  - Relation between disease phenotype and HLA-DQ genotype in diabetic patients 
      diagnosed in early adulthood.
PG  - 2597-605
AB  - We investigated inaugural disease phenotype in relation to the presence or 
      absence of diabetes-associated autoantibodies and human leukocyte antigen (HLA) 
      DQ risk genotypes in adult-onset diabetic patients. Blood samples and 
      questionnaires were obtained from 1584 recent-onset Belgian Caucasian patients 
      (age 15-39 yr at diagnosis of primary diabetes) who were recruited by the Belgian 
      Diabetes Registry over an 11-yr period. At clinical diagnosis, antibody-positive 
      patients (n = 1198) were on average younger and had more symptoms, a more acute 
      disease onset, lower body mass index, and random C-peptide levels, but higher 
      insulin needs, glycemia, and prevalence of ketonuria, HLA-DQ, and 5' insulin gene 
      susceptibility genotypes (P < 0.001 vs. antibody-negative patients; n = 386). In 
      antibody-positive patients, these characteristics did not differ according to 
      HLA-DQ genotype. However, in antibody-negative subjects, we found that patients 
      were younger (P = 0.001); had a lower body mass index (P < 0.001), higher insulin 
      needs (P = 0.014), and amylasemia (P = 0.001); and tended to have a higher 
      glycemia and lower C-peptide in the presence of susceptible HLA-DQ genotypes. 
      Differences according to HLA-DQ genotype subsisted after careful age-matching. In 
      conclusion, we found no relation between initial disease phenotype and HLA-DQ 
      genotype in antibody-positive diabetic young adults. In contrast, 
      antibody-negative patients displayed more type 1-like features when carrying 
      susceptible HLA-DQ genotypes known to promote the development of 
      antibody-positive diabetes. The overrepresentation of these susceptibility 
      genotypes in antibody-negative patients suggests the existence of an 
      immune-mediated disease process with as yet unidentified immune markers in a 
      subgroup of seronegative patients.
FAU - Weets, Ilse
AU  - Weets I
AD  - Diabetes Research Center, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090 
      Brussels, Belgium.
FAU - Siraux, Valerie
AU  - Siraux V
FAU - Daubresse, Jean-Claude
AU  - Daubresse JC
FAU - De Leeuw, Ivo H
AU  - De Leeuw IH
FAU - Fery, Francoise
AU  - Fery F
FAU - Keymeulen, Bart
AU  - Keymeulen B
FAU - Krzentowski, Georges
AU  - Krzentowski G
FAU - Letiexhe, Michel
AU  - Letiexhe M
FAU - Mathieu, Chantal
AU  - Mathieu C
FAU - Nobels, Frank
AU  - Nobels F
FAU - Rottiers, Raoul
AU  - Rottiers R
FAU - Scheen, Andre
AU  - Scheen A
FAU - Van Gaal, Luc
AU  - Van Gaal L
FAU - Schuit, Frans C
AU  - Schuit FC
FAU - Van der Auwera, Bart
AU  - Van der Auwera B
FAU - Rui, Mao
AU  - Rui M
FAU - De Pauw, Pieter
AU  - De Pauw P
FAU - Kaufman, Leonard
AU  - Kaufman L
FAU - Gorus, Frans K
AU  - Gorus FK
CN  - Belgian Diabetes Registry
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Autoantibodies)
RN  - 0 (HLA-DQ Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Autoantibodies/analysis
MH  - Diabetes Mellitus/*genetics/*immunology/physiopathology
MH  - Female
MH  - Genotype
MH  - HLA-DQ Antigens/*genetics
MH  - Humans
MH  - Male
MH  - Phenotype
EDAT- 2002/06/07 10:00
MHDA- 2002/07/04 10:01
CRDT- 2002/06/07 10:00
PHST- 2002/06/07 10:00 [pubmed]
PHST- 2002/07/04 10:01 [medline]
PHST- 2002/06/07 10:00 [entrez]
AID - 10.1210/jcem.87.6.8613 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2002 Jun;87(6):2597-605. doi: 10.1210/jcem.87.6.8613.