PMID- 12053151
OWN - NLM
STAT- MEDLINE
DCOM- 20020715
LR  - 20171101
IS  - 0001-5792 (Print)
IS  - 0001-5792 (Linking)
VI  - 107
IP  - 4
DP  - 2002
TI  - Spectral karyotyping refined the identification of a der(Y)t(Y;1)(q11.1 or.2;q12) 
      in the blast cells of a patient with atypical chronic myeloid leukemia.
PG  - 224-9
AB  - We report a case of atypical chronic myeloid leukemia who showed leukocytosis 
      with immature granulocytes and dysplastic features but no monocytosis or 
      basophilia. Cytogenetic analysis by conventional G-banding showed an abnormal 
      clone, which was interpreted as 46,X,-Y,+der(?)t(?;1)(?;q?1), and no Philadelphia 
      chromosome. Reverse transcription-polymerase chain reaction did not show either 
      major or minor BCR-ABL chimeric mRNA. Spectral karyotyping (SKY) and fluorescence 
      in situ hybridization (FISH) refined the karyotype to 46,X,der(Y)t(Y;1)(q11.1 
      or.2;q12). The der(Y)t(Y;1) abnormality was reported previously in 9 cases and 
      associated with myelodysplastic syndrome or chronic myeloproliferative disorders. 
      SKY in combination with the standard banding method and FISH may be useful for 
      exploring undefined chromosome abnormalities in hematological disorders.
CI  - Copyright 2002 S. Karger AG, Basel
FAU - Ohsaka, Akimichi
AU  - Ohsaka A
AD  - Department of Transfusion Medicine, Juntendo University School of Medicine, 
      Tokyo, Japan. ohsaka@med.juntendo.ac.jp
FAU - Hisa, Tomoko
AU  - Hisa T
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - Switzerland
TA  - Acta Haematol
JT  - Acta haematologica
JID - 0141053
RN  - 0 (Biomarkers, Tumor)
RN  - EC 2.7.10.2 (Fusion Proteins, bcr-abl)
SB  - IM
MH  - Aged
MH  - Biomarkers, Tumor/analysis/genetics
MH  - Bone Marrow/pathology
MH  - Chromosome Banding
MH  - Chromosomes, Human, Pair 1/*ultrastructure
MH  - Fusion Proteins, bcr-abl/analysis
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping/*methods
MH  - Leukemia, Myelogenous, Chronic, BCR-ABL 
      Positive/classification/*genetics/pathology
MH  - Male
MH  - Neoplastic Stem Cells/*ultrastructure
MH  - *Translocation, Genetic
MH  - Y Chromosome/*ultrastructure
RF  - 25
EDAT- 2002/06/08 10:00
MHDA- 2002/07/16 10:01
CRDT- 2002/06/08 10:00
PHST- 2002/06/08 10:00 [pubmed]
PHST- 2002/07/16 10:01 [medline]
PHST- 2002/06/08 10:00 [entrez]
AID - 58319 [pii]
AID - 10.1159/000058319 [doi]
PST - ppublish
SO  - Acta Haematol. 2002;107(4):224-9. doi: 10.1159/000058319.