PMID- 12053279
OWN - NLM
STAT- MEDLINE
DCOM- 20020822
LR  - 20181113
IS  - 1355-0284 (Print)
IS  - 1355-0284 (Linking)
VI  - 8
IP  - 3
DP  - 2002 Jun
TI  - Increased detection of serum HHV-6 DNA sequences during multiple sclerosis (MS) 
      exacerbations and correlation with parameters of MS disease progression.
PG  - 250-6
AB  - In recent years, human herpesvirus 6 (HHV-6) has been investigated as a possible 
      causative agent for MS. To determine if the detection of HHV-6 DNA in the serum 
      of MS patients correlates with clinical parameters of MS disease progression, a 
      total of 215 serum samples was obtained from 59 MS patients followed 
      prospectively for a 5-month period. These samples were analyzed for the presence 
      of HHV-6 DNA by nested PCR and compared in parallel to MS disease activity. HHV-6 
      DNA was amplified in 22% (4/18) of samples obtained during a period of clinical 
      exacerbation. Significantly fewer (P = 0.008) sera, 5.6% (11/197), obtained from 
      MS patients during clinical remission tested positive for the presence of HHV-6 
      DNA. This work demonstrates that the detection of serum HHV-6 DNA is 
      significantly correlated with clinical exacerbations in MS. Moreover, the 
      findings presented in this study have confirmed previous reports supporting an 
      association between MS and HHV-6 and suggest a role for this human herpesvirus in 
      the pathogenesis of MS.
FAU - Berti, Rossana
AU  - Berti R
AD  - Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, 
      National Institutes of Health, Bethesda, Maryland 20892, USA.
FAU - Brennan, Meghan B
AU  - Brennan MB
FAU - Soldan, Samantha S
AU  - Soldan SS
FAU - Ohayon, Joan M
AU  - Ohayon JM
FAU - Casareto, Luca
AU  - Casareto L
FAU - McFarland, Henry F
AU  - McFarland HF
FAU - Jacobson, Steven
AU  - Jacobson S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Neurovirol
JT  - Journal of neurovirology
JID - 9508123
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Base Sequence
MH  - Case-Control Studies
MH  - DNA, Viral/blood
MH  - Disease Progression
MH  - Genes, Viral/genetics
MH  - Herpesvirus 6, Human/growth & development/*isolation & purification
MH  - Humans
MH  - Molecular Sequence Data
MH  - Multiple Sclerosis/*virology
MH  - Prospective Studies
MH  - Roseolovirus Infections/blood/complications/*diagnosis
MH  - Virus Replication
EDAT- 2002/06/08 10:00
MHDA- 2002/08/23 10:01
CRDT- 2002/06/08 10:00
PHST- 2002/06/08 10:00 [pubmed]
PHST- 2002/08/23 10:01 [medline]
PHST- 2002/06/08 10:00 [entrez]
AID - 10.1080/13550280290049615-1 [doi]
PST - ppublish
SO  - J Neurovirol. 2002 Jun;8(3):250-6. doi: 10.1080/13550280290049615-1.