PMID- 120561
OWN - NLM
STAT- MEDLINE
DCOM- 19800616
LR  - 20190918
IS  - 0033-8303 (Print)
IS  - 0033-8303 (Linking)
VI  - 28
IP  - 9
DP  - 1979 Sep 15
TI  - Radiorespirometric analysis of glucose metabolism in the rat during feeding with 
      3'-methyl-4-(dimethylamino)azobenzene--radiorespirometry after partial 
      hepatectomy.
PG  - 546-50
AB  - In previous papers we reported that the earlier peak time (PT) in 
      radiorespiratory during feeding with 
      3'-methyl-4-(dimethylamino)azobenzene(3'-Me-DAB) is due to activation of the 
      hexose monophosphate (HMP) pathway together with hepatic cell proliferation 
      reflecting the toxic effects of this carcinogen. In this study, we investigated 
      the correlation between the results of radiorespiratory and the levels of enzyme 
      activities of HMP pathway in regenerating rat liver in connection with hepatic 
      cell proliferation. [3H]Thymidine incorporation into rat liver DNA and the 
      activities of hexokinase (HK) and glucose-6-phosphate dehydrogenase(G-6-PD) 
      reached a maximum at the 3rd day after partial hepatectomy. On radiorespirometry 
      using [U-14C] glucose, the peak time (PT) was much earlier at the 2nd to 3rd day 
      after partial hepatectomy. The peak height (PH) decreased to less than 1/2 of the 
      initial level at the 2nd, but began to recover from the 3rd day. The yield value 
      (YV) remained below the initial level for 4 days after the operation.
FAU - Kojima, S
AU  - Kojima S
FAU - Yamamoto, M
AU  - Yamamoto M
FAU - Odate, M
AU  - Odate M
FAU - Kubodera, A
AU  - Kubodera A
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Radioisotopes
JT  - Radioisotopes
JID - 20010290R
RN  - 0 (Carbon Radioisotopes)
RN  - 10028-17-8 (Tritium)
RN  - 55-80-1 (Methyldimethylaminoazobenzene)
RN  - 9007-49-2 (DNA)
RN  - A49L8E13FD (p-Dimethylaminoazobenzene)
RN  - EC 1.1.1.49 (Glucosephosphate Dehydrogenase)
RN  - EC 2.7.1.1 (Hexokinase)
RN  - EC 2.7.1.40 (Pyruvate Kinase)
RN  - IY9XDZ35W2 (Glucose)
RN  - VC2W18DGKR (Thymidine)
SB  - IM
MH  - Animals
MH  - *Carbon Radioisotopes
MH  - DNA/biosynthesis
MH  - Glucose/*metabolism
MH  - Glucosephosphate Dehydrogenase/metabolism
MH  - *Hepatectomy
MH  - Hexokinase/metabolism
MH  - Liver/enzymology/metabolism
MH  - Liver Regeneration
MH  - Male
MH  - Methyldimethylaminoazobenzene/*toxicity
MH  - Pyruvate Kinase/metabolism
MH  - Rats
MH  - Spirometry/*methods
MH  - Thymidine/metabolism
MH  - Tritium
MH  - p-Dimethylaminoazobenzene/*analogs & derivatives
EDAT- 1979/09/15 00:00
MHDA- 1979/09/15 00:01
CRDT- 1979/09/15 00:00
PHST- 1979/09/15 00:00 [pubmed]
PHST- 1979/09/15 00:01 [medline]
PHST- 1979/09/15 00:00 [entrez]
AID - 10.3769/radioisotopes.28.9_546 [doi]
PST - ppublish
SO  - Radioisotopes. 1979 Sep 15;28(9):546-50. doi: 10.3769/radioisotopes.28.9_546.