PMID- 12058728
OWN - NLM
STAT- MEDLINE
DCOM- 20030416
LR  - 20190513
IS  - 1369-3786 (Print)
IS  - 1369-3786 (Linking)
VI  - 40
IP  - 2
DP  - 2002 Apr
TI  - Enhanced production of specific IgG4, IgE, IgA and TGF-beta in sera from patients 
      with the juvenile form of paracoccidioidomycosis.
PG  - 153-9
AB  - Paracoccidioidomycosis (PCM) occurs in two distinct forms, the acute or juvenile 
      form (JF), and the chronic or adult form (AF). To clarify the basis of this 
      dichotomy, specific IgG subclasses, IgA and IgE anti-gp43 were measured by 
      enzyme-linked immunosorbent assay, in patients with different forms of PCM. Serum 
      levels of tumor necrosis factor-alpha, interleukin (IL)-6, IL-8, macrophage 
      inflammatory protein (MIP)-1alpha and transforming growth factor (TGF)-beta were 
      also quantified. We show here that JF patients have significantly higher titers 
      of IgE antibodies against gp43, an immunodominant antigen specific for 
      Paracoccidioides brasiliensis, than do patients with the unifocal adult form 
      (UF-AF, isolated lesions). Patients with the multifocal adult form (MF-AF, 
      lesions in more than one organ) also produced elevated levels of anti-P. 
      brasiliensis IgE. Furthermore, specific IgE levels were correlated with IgG4, IgA 
      and eosinophilia. Patients with JF showed eosinophilia and increased levels of 
      TGF-beta, a switching factor for IgA. These results indicate a T helper (Th)-2 
      pattern of cytokine expression in both the JF and the MF-AF of PCM. On the other 
      hand, patients with UF-AF had a significantly lower production of specific IgE, 
      IgG4 and IgA than was seen in the other patient groups.
FAU - Mamoni, R L
AU  - Mamoni RL
AD  - Department of Clinical Pathology, Faculty of Medical Sciences, State University 
      of Campinas (UNICAMP), SP, Brazil.
FAU - Nouer, S A
AU  - Nouer SA
FAU - Oliveira, S J
AU  - Oliveira SJ
FAU - Musatti, C C
AU  - Musatti CC
FAU - Rossi, C L
AU  - Rossi CL
FAU - Camargo, Z P
AU  - Camargo ZP
FAU - Blotta, M H S L
AU  - Blotta MH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Med Mycol
JT  - Medical mycology
JID - 9815835
RN  - 0 (43 kDa protein, Paracoccidioides)
RN  - 0 (Antibodies, Fungal)
RN  - 0 (Antigens, Fungal)
RN  - 0 (Cytokines)
RN  - 0 (Fungal Proteins)
RN  - 0 (Glycoproteins)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Interleukins)
RN  - 0 (Oligosaccharides)
RN  - 0 (Transforming Growth Factor beta)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antibodies, Fungal/*blood
MH  - Antigens, Fungal/immunology
MH  - Child
MH  - Child, Preschool
MH  - Cytokines/immunology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - *Fungal Proteins
MH  - Glycoproteins/immunology
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Immunoglobulin G/classification
MH  - Interleukins/blood
MH  - Male
MH  - Middle Aged
MH  - Oligosaccharides/immunology
MH  - Paracoccidioides/immunology
MH  - Paracoccidioidomycosis/blood/*immunology
MH  - Transforming Growth Factor beta/*blood
EDAT- 2002/06/13 10:00
MHDA- 2003/04/17 05:00
CRDT- 2002/06/13 10:00
PHST- 2002/06/13 10:00 [pubmed]
PHST- 2003/04/17 05:00 [medline]
PHST- 2002/06/13 10:00 [entrez]
AID - 10.1080/mmy.40.2.153.159 [doi]
PST - ppublish
SO  - Med Mycol. 2002 Apr;40(2):153-9. doi: 10.1080/mmy.40.2.153.159.