PMID- 12059144
OWN - NLM
STAT- MEDLINE
DCOM- 20020724
LR  - 20190723
IS  - 0021-8561 (Print)
IS  - 0021-8561 (Linking)
VI  - 50
IP  - 13
DP  - 2002 Jun 19
TI  - Inhibition of low-density lipoprotein oxidation and up-regulation of low-density 
      lipoprotein receptor in HepG2 cells by tropical plant extracts.
PG  - 3693-7
AB  - Twelve edible plant extracts rich in polyphenols were screened for their 
      potential to inhibit oxidation of low-density lipoprotein (LDL) in vitro and to 
      modulate LDL receptor (LDLr) activity in cultured HepG2 cells. The antioxidant 
      activity (inhibition of LDL oxidation) was determined by measuring the formation 
      of conjugated dienes (lag time) and thiobarbituric acid reagent substances 
      (TBARS). Betel leaf (94%), cashew shoot (63%), Japanese mint (52%), semambu leaf 
      (50%), palm frond (41%), sweet potato shoot, chilli fruit, papaya shoot, roselle 
      calyx, and maman showed significantly increased lag time (>55 min, P < 0.05) and 
      inhibition of TBARS formation (P < 0.05) compared to control. LDLr was 
      significantly up-regulated (P < 0.05) by Japanese mint (67%), semambu (51%), 
      cashew (50%), and noni (49%). Except for noni and betel leaf, most plant extracts 
      studied demonstrated a positive association between antioxidant activity and the 
      ability to up-regulate LDL receptor. Findings suggest that reported protective 
      actions of plant polyphenols on lipoprotein metabolism might be exerted at 
      different biochemical mechanisms.
FAU - Salleh, Mohd Nizar
AU  - Salleh MN
AD  - Department of Food Science, University Putra Malaysia, 43400 Serdang, Selangor, 
      Malaysia, Australia.
FAU - Runnie, Irine
AU  - Runnie I
FAU - Roach, Paul D
AU  - Roach PD
FAU - Mohamed, Suhaila
AU  - Mohamed S
FAU - Abeywardena, Mahinda Y
AU  - Abeywardena MY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Agric Food Chem
JT  - Journal of agricultural and food chemistry
JID - 0374755
RN  - 0 (Antioxidants)
RN  - 0 (Lipoproteins, LDL)
RN  - 0 (Plant Extracts)
RN  - 0 (Receptors, LDL)
RN  - 0 (Tea)
RN  - 0 (Thiobarbituric Acid Reactive Substances)
RN  - 789U1901C5 (Copper)
SB  - IM
MH  - Adult
MH  - Antioxidants/*pharmacology
MH  - Carcinoma, Hepatocellular/metabolism
MH  - Copper/chemistry
MH  - Humans
MH  - Kinetics
MH  - Lipid Peroxidation/*drug effects
MH  - Lipoproteins, LDL/*chemistry/metabolism
MH  - Liver Neoplasms/metabolism
MH  - Plant Extracts/*pharmacology
MH  - Plants, Edible/chemistry
MH  - Receptors, LDL/*metabolism
MH  - Tea/chemistry
MH  - Thiobarbituric Acid Reactive Substances/metabolism
MH  - *Tropical Climate
MH  - Tumor Cells, Cultured
EDAT- 2002/06/13 10:00
MHDA- 2002/07/26 10:01
CRDT- 2002/06/13 10:00
PHST- 2002/06/13 10:00 [pubmed]
PHST- 2002/07/26 10:01 [medline]
PHST- 2002/06/13 10:00 [entrez]
AID - jf011593f [pii]
AID - 10.1021/jf011593f [doi]
PST - ppublish
SO  - J Agric Food Chem. 2002 Jun 19;50(13):3693-7. doi: 10.1021/jf011593f.