PMID- 12059860
OWN - NLM
STAT- MEDLINE
DCOM- 20020812
LR  - 20220309
IS  - 1395-3907 (Print)
IS  - 1395-3907 (Linking)
VI  - 80
IP  - 3
DP  - 2002 Jun
TI  - Growth factors in corneal wound healing following refractive surgery: A review.
PG  - 238-47
AB  - The first part of this review article aims to provide important basic definitions 
      of growth factor terminology, and to put forward a model for understanding the 
      role of growth factors in a wound healing context. In the second part of the 
      paper, we review the literature on growth factors in the cornea, including that 
      on changes associated with wound healing following refractive surgery in the 
      epithelial, stromal, and endothelial layers. The role of growth factors in 
      stromal removal, corneal neovascularization, corneal innervation and wound 
      healing is considered. The importance of the epithelial-stromal interaction is 
      discussed, including the role of growth factors in keratocyte apoptosis. In the 
      final section, we review the current literature on endogenous and exogenous 
      modulation of growth factors in corneal wound healing. This includes important in 
      vitro work but aims to emphasize clinically relevant results. Photorefractive 
      keratectomy (PRK) may have short-term complications such as pain and haze, 
      whereas laser in situ keratomilieusis (LASIK) may have longer-term adverse 
      effects on corneal biomechanics. The emerging technique of laser epithelial 
      keratomilieusis (LASEK) provides an interesting alternative wound which may be 
      less susceptible to the inherent complications of PRK and LASIK. At present, the 
      phenomenon of iatrogenic keratectasia following LASIK is not fully understood, 
      but these features of wound healing following PRK may be amenable to growth 
      factor modulation.
FAU - Baldwin, Heather C
AU  - Baldwin HC
AD  - Ophthalmology, Rayne Institute, St Thomas' Hospital, London, UK. 
      baldwinhc@aol.com
FAU - Marshall, John
AU  - Marshall J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Denmark
TA  - Acta Ophthalmol Scand
JT  - Acta ophthalmologica Scandinavica
JID - 9507578
RN  - 0 (Growth Substances)
SB  - IM
MH  - Animals
MH  - Cell Communication
MH  - Cornea/*physiology/surgery
MH  - Corneal Stroma/metabolism
MH  - Epithelium, Corneal/metabolism
MH  - Growth Substances/*physiology
MH  - Humans
MH  - Keratomileusis, Laser In Situ
MH  - Lasers, Excimer
MH  - Photorefractive Keratectomy
MH  - Refractive Errors/*metabolism
MH  - *Refractive Surgical Procedures
MH  - Wound Healing/*physiology
RF  - 129
EDAT- 2002/06/13 10:00
MHDA- 2002/08/13 10:01
CRDT- 2002/06/13 10:00
PHST- 2002/06/13 10:00 [pubmed]
PHST- 2002/08/13 10:01 [medline]
PHST- 2002/06/13 10:00 [entrez]
AID - 800303 [pii]
AID - 10.1034/j.1600-0420.2002.800303.x [doi]
PST - ppublish
SO  - Acta Ophthalmol Scand. 2002 Jun;80(3):238-47. doi: 
      10.1034/j.1600-0420.2002.800303.x.