PMID- 12060426
OWN - NLM
STAT- MEDLINE
DCOM- 20021016
LR  - 20190901
IS  - 0303-6979 (Print)
IS  - 0303-6979 (Linking)
VI  - 29
IP  - 5
DP  - 2002 May
TI  - Supracrestal soft tissue preservation with enamel matrix proteins in treatment of 
      deep intrabony defects.
PG  - 433-9
AB  - BACKGROUND/AIMS: The purpose of the present study was to investigate the 
      effectiveness of a regenerative procedure based on supracrestal soft tissue 
      preservation in association with enamel matrix proteins (EMP) in the treatment of 
      deep intrabony defects. METHODS: The subjects included 35 consecutively treated 
      patients, 23 females and 12 males, aged 28-61 years, 11 of whom were smokers. 
      Patients presented with at least one intrabony defect with probing pocket depth > 
      or = 6 mm and a radiographic depth of the defect > or = 4 mm at the initial 
      visit. Immediately before surgery and 9-12 months after surgery, Local Plaque 
      Score (LPS), Local Bleeding Score (LBS), probing pocket depth (PPD), clinical 
      attachment level (CAL), gingival recession (REC), and radiographic depth of the 
      defect (DEPTH) were recorded. RESULTS: Thirty-one (88.6%) defects were 
      LPS-negative presurgery, while 29 (82.9%) defects presented with no plaque 
      postsurgery. The prevalence of LBS-positive defects shifted from 94.3% presurgery 
      to 8.4% postsurgery (p < 0.0000). PPD was 8.9 mm before surgery, and decreased to 
      3.5 mm postsurgery (p < 0.0000). CAL varied from 10.1 mm presurgery to 5.4 mm 
      postsurgery (p < 0.0000), with an average improvement (gain) of 4.7 +/- 1.7 mm. 
      Twenty-six (74.3%) defects presented a gain of least 4 mm. Regression analysis 
      showed a positive correlation between CAL gain as a dependent variable, and 
      presurgery PPD and amount of supracrestal soft tissues as predictors. DEPTH 
      improvement (gain) was 3.9 +/- 1.8 mm, which represented 65% of defect fill. 
      Twenty (57.1%) defects presented a DEPTH gain of at least 4 mm. DEPTH gain was 
      significantly correlated to presurgery PPD (p < 0.000). No significant 
      differences were found between smokers and non-smokers in terms of CAL and DEPTH 
      gain. CONCLUSIONS: Results from the present study indicated that the regenerative 
      procedure based on supracrestal soft tissue preservation and EMP application 
      leads to clinically and statistically significant improvement of hard and soft 
      tissue conditions of deep intrabony defects.
FAU - Trombelli, Leonardo
AU  - Trombelli L
AD  - Research Centre for the Study of Periodontal Diseases, University of Ferrara, 
      Ferrara, Italy.
FAU - Bottega, Sabrina
AU  - Bottega S
FAU - Zucchelli, Giovanni
AU  - Zucchelli G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Clin Periodontol
JT  - Journal of clinical periodontology
JID - 0425123
RN  - 0 (Bone Substitutes)
RN  - 0 (Dental Enamel Proteins)
RN  - 0 (enamel matrix proteins)
SB  - IM
MH  - Adult
MH  - Alveolar Bone Loss/diagnostic imaging/pathology/*surgery
MH  - Analysis of Variance
MH  - Bone Substitutes/*therapeutic use
MH  - Dental Enamel Proteins/*therapeutic use
MH  - Dental Plaque Index
MH  - Female
MH  - Follow-Up Studies
MH  - Gingival Recession/pathology/surgery
MH  - Guided Tissue Regeneration, Periodontal/methods
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Periodontal Attachment Loss/pathology/surgery
MH  - Periodontal Diseases/pathology/*surgery
MH  - Periodontal Index
MH  - Periodontal Pocket/pathology/surgery
MH  - Radiography
MH  - Regression Analysis
MH  - Smoking
MH  - Statistics as Topic
MH  - Surgical Flaps
MH  - Suture Techniques
MH  - Treatment Outcome
MH  - Wound Healing
EDAT- 2002/06/13 10:00
MHDA- 2002/10/17 04:00
CRDT- 2002/06/13 10:00
PHST- 2002/06/13 10:00 [pubmed]
PHST- 2002/10/17 04:00 [medline]
PHST- 2002/06/13 10:00 [entrez]
AID - cpe290508 [pii]
AID - 10.1034/j.1600-051x.2002.290508.x [doi]
PST - ppublish
SO  - J Clin Periodontol. 2002 May;29(5):433-9. doi: 10.1034/j.1600-051x.2002.290508.x.