PMID- 12060495
OWN - NLM
STAT- MEDLINE
DCOM- 20021204
LR  - 20141120
IS  - 1079-9907 (Print)
IS  - 1079-9907 (Linking)
VI  - 22
IP  - 5
DP  - 2002 May
TI  - Cytokine responses in young and old rhesus monkeys: effect of caloric 
      restriction.
PG  - 565-71
AB  - Caloric restriction (CR) is the only known intervention demonstrated to retard a 
      great variety of aging processes, extend median and maximum life-span, and 
      decrease the incidence of age-associated diseases in mammals. Paralleling 
      findings from rodent studies, studies in rhesus monkeys (Macaca mulatta) suggest 
      that CR may retard many age-sensitive parameters in primates. A recent study in 
      rhesus monkeys showed age-related dysregulation of cytokine levels. Specifically, 
      age-related increases in interleukin-10 (IL-10) and IL-6 proteins were observed 
      in supernatants from lipopolysaccharide (LPS)-stimulated peripheral blood 
      mononuclear cells (PBMCs), and interferon-gamma (IFN-gamma) protein exhibited an 
      age-related decrease in phytohemagglutinin (PHA)-stimulated PBMCs. To investigate 
      effects of CR on age-related changes in cytokine production, we obtained PBMCs 
      from control and CR rhesus monkeys aged 6-7 and 22-25 years. We evaluated IL-10 
      and IL-6 protein and gene expression after exposure to LPS and IFN-gamma protein 
      and gene expression after PHA stimulation. The results revealed significantly 
      higher levels of IFN-gamma protein and gene expression in aged monkeys on CR for 
      2 years compared with controls. No significant CR effects were observed on IL-10 
      and IL-6 protein levels. IFN-gamma plays an important role in the initial defense 
      mechanism against viral and microbial disease and cancer. Altered regulation of 
      IFN-gamma in old CR rhesus monkeys may be a key factor in reducing cancer 
      incidence and other age-associated diseases.
FAU - Mascarucci, Paolo
AU  - Mascarucci P
AD  - Laboratory of Neurosciences, Gerontology Research Center, National Institute on 
      Aging, NIH, Baltimore, MD 21224, USA.
FAU - Taub, Dennis
AU  - Taub D
FAU - Saccani, Simona
AU  - Saccani S
FAU - Paloma, Marjorie A
AU  - Paloma MA
FAU - Dawson, Harry
AU  - Dawson H
FAU - Roth, George S
AU  - Roth GS
FAU - Lane, Mark A
AU  - Lane MA
FAU - Ingram, Donald K
AU  - Ingram DK
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Interferon Cytokine Res
JT  - Journal of interferon & cytokine research : the official journal of the 
      International Society for Interferon and Cytokine Research
JID - 9507088
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-6)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Phytohemagglutinins)
RN  - 130068-27-8 (Interleukin-10)
RN  - 63231-63-0 (RNA)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Aging/genetics/*immunology
MH  - Animals
MH  - *Caloric Restriction
MH  - Cytokines/*biosynthesis/genetics
MH  - Gene Expression/drug effects
MH  - In Vitro Techniques
MH  - Interferon-gamma/biosynthesis/genetics
MH  - Interleukin-10/biosynthesis/genetics
MH  - Interleukin-6/biosynthesis/genetics
MH  - Leukocytes, Mononuclear/drug effects/immunology
MH  - Lipopolysaccharides/pharmacology
MH  - Macaca mulatta/genetics/*immunology
MH  - Male
MH  - Phytohemagglutinins/pharmacology
MH  - RNA/genetics/metabolism
EDAT- 2002/06/13 10:00
MHDA- 2002/12/05 04:00
CRDT- 2002/06/13 10:00
PHST- 2002/06/13 10:00 [pubmed]
PHST- 2002/12/05 04:00 [medline]
PHST- 2002/06/13 10:00 [entrez]
AID - 10.1089/10799900252982043 [doi]
PST - ppublish
SO  - J Interferon Cytokine Res. 2002 May;22(5):565-71. doi: 10.1089/10799900252982043.