PMID- 12062820
OWN - NLM
STAT- MEDLINE
DCOM- 20021001
LR  - 20191025
IS  - 0165-0378 (Print)
IS  - 0165-0378 (Linking)
VI  - 55
IP  - 1-2
DP  - 2002 May-Jun
TI  - IL-1beta during in vitro decidualization in primate.
PG  - 35-47
AB  - The sequence of biochemical and molecular events associated with decidualization 
      in the primate remain unclear. In the baboon, the sequential changes during this 
      period in vivo are characterized by the downregulation of alpha-smooth actin 
      followed by induction of cyclooxygenase-2 (COX-2) at the implantation site and 
      the expression of insulin growth factor binding protein-1 (IGFBP-1). IGFBP-1 is 
      the predominant protein in decidualized cells and is considered to be biochemical 
      marker of decidualization. In the baboon the expression of IGFBP-1 requires the 
      presence of a conceptus in vivo or N(6), 2'-O-dibutyryladenosine 3:5'-cyclic 
      monophosphate (dbcAMP) in the presence of hormones in vitro. In addition 
      IL-1beta, as a possible conceptus-mediated factor, can induce IGFBP-1 expression 
      in the presence of hormones following 3 days of incubation. However, if IL-1beta 
      and dbcAMP are added together, IGFBP-1 expression is inhibited which resulted in 
      IL-1beta being considered to be "inhibitory" to decidualization. Current data 
      suggest that IL-1beta can activate multiple signaling pathways that either 
      positively (no exogenous cAMP) or negatively (in presence of exogenous cAMP) 
      regulate IGFBP-1 gene expression and decidualization in vitro. Signaling pathways 
      activated by IL-1beta following 10 min of stimulation result in the 
      phosphorylation of mitogen-activated protein kinase (MAPK, specifically p38 MAPK) 
      and also lead to NF-kappaB activation. The expression of COX-2 and matrix 
      metalloproteinase-3 (MMP-3) genes follows after 4-6 h. The steroid hormones, 
      particularly progesterone, which are critical for IGFBP-1 expression, modulate 
      the activity of IL-1beta by down-regulating MMP-3 activity. Disruption of actin 
      filaments enhances IGFBP-1 induction during decidualization. IL-1beta induced 
      MMP-3 may upregulate IGFBP-1 by initiation of cytoskeletal reorganization through 
      degradation of extracellular matrix (ECM). Inhibition of IL-1beta induced 
      pathways leads to reduction of IGFBP-1 expression, suggesting that IL-1beta may 
      be involved in the events leading to decidualization in baboons.
FAU - Strakova, Z
AU  - Strakova Z
AD  - Department of Obstetrics and Gynecology, The University of Illinois at Chicago, 
      820 South Wood Street (M/C 808), Chicago, IL 60612-7313, USA. zstrakov@uic.edu
FAU - Srisuparp, S
AU  - Srisuparp S
FAU - Fazleabas, A T
AU  - Fazleabas AT
LA  - eng
GR  - HD 36759/HD/NICHD NIH HHS/United States
GR  - HD 39851-01/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - Ireland
TA  - J Reprod Immunol
JT  - Journal of reproductive immunology
JID - 8001906
RN  - 0 (Il1rn protein, mouse)
RN  - 0 (Insulin-Like Growth Factor Binding Protein 1)
RN  - 0 (Interleukin 1 Receptor Antagonist Protein)
RN  - 0 (Interleukin-1)
RN  - 0 (Isoenzymes)
RN  - 0 (Receptors, Interleukin-1)
RN  - 0 (Sialoglycoproteins)
RN  - 63X7MBT2LQ (Bucladesine)
RN  - EC 1.14.99.1 (Cyclooxygenase 2)
RN  - EC 1.14.99.1 (Prostaglandin-Endoperoxide Synthases)
SB  - IM
MH  - Animals
MH  - Bucladesine/pharmacology
MH  - Cyclooxygenase 2
MH  - Decidua/drug effects/*immunology/physiology
MH  - Embryo Implantation/drug effects/*immunology/physiology
MH  - Endometrium/metabolism
MH  - Female
MH  - In Vitro Techniques
MH  - Insulin-Like Growth Factor Binding Protein 1/metabolism
MH  - Interleukin 1 Receptor Antagonist Protein
MH  - Interleukin-1/deficiency/pharmacology/*physiology
MH  - Isoenzymes/metabolism
MH  - Mice
MH  - Mice, Knockout
MH  - Models, Biological
MH  - Papio/*immunology/physiology
MH  - Pregnancy
MH  - Prostaglandin-Endoperoxide Synthases/metabolism
MH  - Receptors, Interleukin-1/deficiency
MH  - Sialoglycoproteins/deficiency
MH  - Signal Transduction
RF  - 75
EDAT- 2002/06/14 10:00
MHDA- 2002/10/03 04:00
CRDT- 2002/06/14 10:00
PHST- 2002/06/14 10:00 [pubmed]
PHST- 2002/10/03 04:00 [medline]
PHST- 2002/06/14 10:00 [entrez]
AID - S0165037801001413 [pii]
AID - 10.1016/s0165-0378(01)00141-3 [doi]
PST - ppublish
SO  - J Reprod Immunol. 2002 May-Jun;55(1-2):35-47. doi: 10.1016/s0165-0378(01)00141-3.