PMID- 12065360
OWN - NLM
STAT- MEDLINE
DCOM- 20020827
LR  - 20190514
IS  - 0012-3692 (Print)
IS  - 0012-3692 (Linking)
VI  - 121
IP  - 6
DP  - 2002 Jun
TI  - Value of Doppler index combining systolic and diastolic myocardial performance in 
      predicting cardiopulmonary exercise capacity in patients with congestive heart 
      failure: effects of dobutamine.
PG  - 1935-41
AB  - STUDY OBJECTIVE: Doppler-derived myocardial performance index (MPI), a measure of 
      combined systolic and diastolic myocardial performance, was assessed at rest and 
      after low-dose dobutamine administration in patients with idiopathic or ischemic 
      dilated cardiomyopathy. MPI also was correlated with other conventional 
      echocardiographic indexes of left ventricular (LV) function, and its ability to 
      assess cardiopulmonary exercise capacity in those patients was investigated. 
      SETTINGS: A tertiary-care, university heart failure clinic. PATIENTS: Forty-two 
      consecutive patients (27 men; mean [+/- SD] age, 57 +/- 10 years) with heart 
      failure (New York Heart Association [NYHA] class, II to IV) who had received 
      echocardiographic diagnoses of dilated cardiomyopathy. Coronary angiography 
      distinguished the cause of dilated cardiomyopathy. INTERVENTIONS: Low-dose IV 
      dobutamine was infused after patients underwent a baseline echocardiographic 
      study. All patients also underwent a cardiopulmonary exercise test using a 
      modified Naughton protocol. RESULTS: Advanced NYHA class and restrictive LV 
      filling pattern were associated with higher index values. A negative correlation 
      was found between MPI and LV stroke volume, cardiac output, early filling/late 
      filling velocity ratio, and late LV filling velocity, as well as oxygen uptake at 
      peak exercise (r = -0.550; p < 0.001) and at the anaerobic threshold (r = -0.490; 
      p = 0.002). Dobutamine administration produced an improvement in MPI, reducing 
      its value and decreasing the isovolumic relaxation and contraction times. 
      Stepwise regression analysis revealed that the rest index and the late LV filling 
      velocity were the only independent predictors of cardiopulmonary exercise 
      capacity. CONCLUSION: MPI correlates inversely with LV performance, reflects 
      disease severity, and is a useful complimentary variable in the assessment of 
      cardiopulmonary exercise performance in patients with heart failure.
FAU - Parthenakis, Fragiskos I
AU  - Parthenakis FI
AD  - Cardiology Department, Heraklion University Hospital, Stavrakia, Crete, Greece.
FAU - Kanakaraki, Marina K
AU  - Kanakaraki MK
FAU - Kanoupakis, Emmanuel M
AU  - Kanoupakis EM
FAU - Skalidis, Emmanuel I
AU  - Skalidis EI
FAU - Diakakis, George F
AU  - Diakakis GF
FAU - Filippou, Olvia K
AU  - Filippou OK
FAU - Vardas, Panos E
AU  - Vardas PE
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Chest
JT  - Chest
JID - 0231335
RN  - 0 (Adrenergic beta-Agonists)
RN  - 3S12J47372 (Dobutamine)
SB  - IM
MH  - Adrenergic beta-Agonists
MH  - Dobutamine
MH  - *Echocardiography, Doppler
MH  - *Exercise Test
MH  - Female
MH  - Heart/physiopathology
MH  - Heart Failure/*diagnostic imaging/*physiopathology
MH  - Humans
MH  - Lung/physiopathology
MH  - Male
MH  - Middle Aged
MH  - *Myocardial Contraction
MH  - Predictive Value of Tests
MH  - Severity of Illness Index
EDAT- 2002/06/18 10:00
MHDA- 2002/08/28 10:01
CRDT- 2002/06/18 10:00
PHST- 2002/06/18 10:00 [pubmed]
PHST- 2002/08/28 10:01 [medline]
PHST- 2002/06/18 10:00 [entrez]
AID - S0012-3692(15)35029-7 [pii]
AID - 10.1378/chest.121.6.1935 [doi]
PST - ppublish
SO  - Chest. 2002 Jun;121(6):1935-41. doi: 10.1378/chest.121.6.1935.