PMID- 12068291
OWN - NLM
STAT- MEDLINE
DCOM- 20020730
LR  - 20071108
IS  - 1529-2908 (Print)
IS  - 1529-2908 (Linking)
VI  - 3
IP  - 7
DP  - 2002 Jul
TI  - The crystal structure of IgE Fc reveals an asymmetrically bent conformation.
PG  - 681-6
AB  - The distinguishing structural feature of immunoglobulin E (IgE), the antibody 
      responsible for allergic hypersensitivity, is the C epsilon 2 domain pair that 
      replaces the hinge region of IgG. The crystal structure of the IgE Fc (constant 
      fragment) at a 2.6-A resolution has revealed these domains. They display a 
      distinctive, disulfide-linked Ig domain interface and are folded back 
      asymmetrically onto the C epsilon 3 and C epsilon 4 domains, which causes an 
      acute bend in the IgE molecule. The structure implies that a substantial 
      conformational change involving C epsilon 2 must accompany binding to the mast 
      cell receptor Fc epsilon RI. This may be the basis of the exceptionally slow 
      dissociation rate of the IgE-Fc epsilon RI complex and, thus, of the ability of 
      IgE to cause persistent allergic sensitization of mast cells.
FAU - Wan, Tommy
AU  - Wan T
AD  - The Randall Centre, King's College London, New Hunt's House, London SE1 1UL, UK.
FAU - Beavil, Rebecca L
AU  - Beavil RL
FAU - Fabiane, Stella M
AU  - Fabiane SM
FAU - Beavil, Andrew J
AU  - Beavil AJ
FAU - Sohi, Maninder K
AU  - Sohi MK
FAU - Keown, Maura
AU  - Keown M
FAU - Young, Robert J
AU  - Young RJ
FAU - Henry, Alistair J
AU  - Henry AJ
FAU - Owens, Ray J
AU  - Owens RJ
FAU - Gould, Hannah J
AU  - Gould HJ
FAU - Sutton, Brian J
AU  - Sutton BJ
LA  - eng
SI  - PDB/1LS0
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20020617
PL  - United States
TA  - Nat Immunol
JT  - Nature immunology
JID - 100941354
RN  - 0 (Immunoglobulin Constant Regions)
RN  - 0 (Receptors, IgE)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
CIN - Nat Immunol. 2002 Jul;3(7):607-8. PMID: 12087417
MH  - Carbohydrate Conformation
MH  - Crystallography, X-Ray
MH  - Dimerization
MH  - Humans
MH  - Immunoglobulin Constant Regions/*chemistry
MH  - Immunoglobulin E/*chemistry
MH  - Models, Molecular
MH  - Protein Structure, Tertiary
MH  - Receptors, IgE/chemistry
EDAT- 2002/06/18 10:00
MHDA- 2002/07/31 10:01
CRDT- 2002/06/18 10:00
PHST- 2002/06/18 10:00 [pubmed]
PHST- 2002/07/31 10:01 [medline]
PHST- 2002/06/18 10:00 [entrez]
AID - ni811 [pii]
AID - 10.1038/ni811 [doi]
PST - ppublish
SO  - Nat Immunol. 2002 Jul;3(7):681-6. doi: 10.1038/ni811. Epub 2002 Jun 17.