PMID- 12069949
OWN - NLM
STAT- MEDLINE
DCOM- 20020716
LR  - 20200930
IS  - 0363-6119 (Print)
IS  - 0363-6119 (Linking)
VI  - 283
IP  - 1
DP  - 2002 Jul
TI  - Respiratory changes induced by kainic acid lesions in rostral ventral respiratory 
      group of rabbits.
PG  - R227-42
AB  - The role played by the Botzinger complex (BotC), the pre-Botzinger complex 
      (pre-BotC), and the more rostral extent of the inspiratory portion of the ventral 
      respiratory group (iVRG) in the genesis of the eupneic pattern of breathing was 
      investigated in anesthetized, vagotomized, paralyzed, and artificially ventilated 
      rabbits by means of kainic acid (KA, 4.7 mM) microinjections (20-30 nl). 
      Unilateral KA microinjections into all of the investigated VRG subregions caused 
      increases in respiratory frequency associated with moderate decreases in peak 
      phrenic amplitude in the BotC and pre-BotC regions. Bilateral KA microinjections 
      into either the BotC or pre-BotC transiently eliminated respiratory rhythmicity 
      and caused the appearance of tonic phrenic activity ("tonic apnea"), whereas 
      injections into the rostral iVRG completely suppressed inspiratory activity. 
      Rhythmic activity resumed as low-amplitude, high-frequency oscillations and 
      displayed a progressive, although incomplete, recovery. Combined bilateral KA 
      microinjections (BotC and pre-BotC) caused persistent (>3 h) tonic apnea. Results 
      show that all of the investigated VRG subregions exert a potent control on both 
      the intensity and frequency of inspiratory activity, thus suggesting that these 
      areas play a major role in the genesis of the eupneic pattern of breathing.
FAU - Mutolo, Donatella
AU  - Mutolo D
AD  - Dipartimento di Scienze Fisiologiche, Universita degli Studi di Firenze, Viale 
      G.B. Morgagni 63, I-50134 Florence, Italy.
FAU - Bongianni, Fulvia
AU  - Bongianni F
FAU - Carfi, Marco
AU  - Carfi M
FAU - Pantaleo, Tito
AU  - Pantaleo T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Physiol Regul Integr Comp Physiol
JT  - American journal of physiology. Regulatory, integrative and comparative 
      physiology
JID - 100901230
RN  - SIV03811UC (Kainic Acid)
SB  - IM
MH  - Animals
MH  - Blood Pressure/drug effects
MH  - Cardiovascular Physiological Phenomena
MH  - Kainic Acid/pharmacology
MH  - Male
MH  - Medulla Oblongata/*drug effects/pathology/*physiology
MH  - Microinjections
MH  - Neurons/physiology
MH  - Rabbits
MH  - Respiration/drug effects
MH  - *Respiratory Physiological Phenomena
MH  - Respiratory System/innervation
EDAT- 2002/06/19 10:00
MHDA- 2002/07/18 10:01
CRDT- 2002/06/19 10:00
PHST- 2002/06/19 10:00 [pubmed]
PHST- 2002/07/18 10:01 [medline]
PHST- 2002/06/19 10:00 [entrez]
AID - 10.1152/ajpregu.00579.2001 [doi]
PST - ppublish
SO  - Am J Physiol Regul Integr Comp Physiol. 2002 Jul;283(1):R227-42. doi: 
      10.1152/ajpregu.00579.2001.