PMID- 12070113
OWN - NLM
STAT- MEDLINE
DCOM- 20020628
LR  - 20190623
IS  - 1524-4539 (Electronic)
IS  - 0009-7322 (Linking)
VI  - 105
IP  - 24
DP  - 2002 Jun 18
TI  - Initial clinical experience with the Jarvik 2000 implantable axial-flow left 
      ventricular assist system.
PG  - 2855-60
AB  - BACKGROUND: Implantable left ventricular assist systems (LVASs) are used for 
      bridging to transplantation, bridging to myocardial improvement, and for 
      permanent circulatory support. Conventional implantable systems have inherent 
      limitations that increase morbidity during support. In contrast, small, 
      efficient, axial-flow pumps, which have been under development for the past 
      decade, have the potential to improve the length and quality of life in patients 
      with severe heart failure. Methods and Results- To assess the safety and clinical 
      utility of the Jarvik 2000, we implanted this device in 10 transplant candidates 
      (mean age 51.3 years) in New York Heart Association (NYHA) class IV. Implantation 
      was achieved through a left thoracotomy during partial cardiopulmonary bypass. 
      The mean support period was 84 days. Within 48 hours postoperatively, the cardiac 
      index increased 43%, pulmonary capillary wedge pressure decreased 52%, systemic 
      vascular resistance decreased significantly, and inotropic support became 
      unnecessary. Eight patients underwent physical rehabilitation and returned to 
      NYHA class I. Their left ventricular dimensions, cardiothoracic ratios, and 
      pressure-volume loop analyses showed good left ventricular unloading. Seven 
      patients underwent transplantation and 3 died during support. No device 
      thrombosis was observed at explantation. CONCLUSIONS: The Jarvik 2000 functions 
      as a true assist device by partially unloading the left ventricle, thereby 
      optimizing the patient's hemodynamics. Our preliminary results indicate that this 
      LVAS may safely provide circulatory assistance for heart transplant candidates.
FAU - Frazier, O H
AU  - Frazier OH
AD  - Cullen Cardiovascular Surgical Research Laboratories, Texas Heart Institute, 
      Houston, USA.
FAU - Myers, Timothy J
AU  - Myers TJ
FAU - Gregoric, Igor D
AU  - Gregoric ID
FAU - Khan, Tehreen
AU  - Khan T
FAU - Delgado, Reynolds
AU  - Delgado R
FAU - Croitoru, Mihai
AU  - Croitoru M
FAU - Miller, Kathy
AU  - Miller K
FAU - Jarvik, Robert
AU  - Jarvik R
FAU - Westaby, Stephen
AU  - Westaby S
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - United States
TA  - Circulation
JT  - Circulation
JID - 0147763
SB  - IM
CIN - Circulation. 2002 Jun 18;105(24):2808-9. PMID: 12070103
MH  - Adult
MH  - Female
MH  - Heart Failure/*surgery
MH  - *Heart Ventricles
MH  - *Heart-Assist Devices/adverse effects
MH  - Hemodynamics
MH  - Hemorrhage/etiology
MH  - Humans
MH  - Kinetics
MH  - Male
MH  - Middle Aged
MH  - Prosthesis Implantation
EDAT- 2002/06/19 10:00
MHDA- 2002/06/29 10:01
CRDT- 2002/06/19 10:00
PHST- 2002/06/19 10:00 [pubmed]
PHST- 2002/06/29 10:01 [medline]
PHST- 2002/06/19 10:00 [entrez]
AID - 10.1161/01.cir.0000018167.47314.af [doi]
PST - ppublish
SO  - Circulation. 2002 Jun 18;105(24):2855-60. doi: 
      10.1161/01.cir.0000018167.47314.af.