PMID- 12070121
OWN - NLM
STAT- MEDLINE
DCOM- 20020628
LR  - 20190623
IS  - 1524-4539 (Electronic)
IS  - 0009-7322 (Linking)
VI  - 105
IP  - 24
DP  - 2002 Jun 18
TI  - Essential role of monocyte chemoattractant protein-1 in development of restenotic 
      changes (neointimal hyperplasia and constrictive remodeling) after balloon 
      angioplasty in hypercholesterolemic rabbits.
PG  - 2905-10
AB  - BACKGROUND: Renarrowing of dilated arterial sites (restenosis) hampers the 
      clinical benefits of coronary angioplasty. Infiltration and activation of 
      monocytes in the arterial wall mediated by monocyte chemoattractant protein-1 
      (MCP-1) might be a major cause of restenosis after angioplasty. However, there is 
      no direct evidence to support a definite role of MCP-1 in the development of 
      restenosis. Methods and Results- We recently devised a new strategy for 
      anti-MCP-1 gene therapy by transfecting an N-terminal deletion mutant of the 
      MCP-1 gene into skeletal muscles. We used this strategy to investigate the role 
      of MCP-1 in the development of restenotic changes after balloon injury in the 
      carotid artery in hypercholesterolemic rabbits. Intramuscular transfection of the 
      mutant MCP-1 gene suppressed monocyte infiltration/activation in the injured 
      arterial wall and thus attenuated the development of neointimal hyperplasia and 
      negative remodeling. CONCLUSIONS: MCP-1-mediated monocyte infiltration is 
      necessary in the development of restenotic changes to balloon injury in 
      hypercholesterolemic rabbits. This strategy may be a useful and practical form of 
      gene therapy against human restenosis.
FAU - Mori, Emiko
AU  - Mori E
AD  - Department of Surgery and Science, Kyushu University School of Medical Sciences, 
      Fukuoka, Japan.
FAU - Komori, Kimihiro
AU  - Komori K
FAU - Yamaoka, Terutoshi
AU  - Yamaoka T
FAU - Tanii, Mitsugu
AU  - Tanii M
FAU - Kataoka, Chu
AU  - Kataoka C
FAU - Takeshita, Akira
AU  - Takeshita A
FAU - Usui, Makoto
AU  - Usui M
FAU - Egashira, Kensuke
AU  - Egashira K
FAU - Sugimachi, Keizo
AU  - Sugimachi K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Circulation
JT  - Circulation
JID - 0147763
RN  - 0 (Chemokine CCL2)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Angioplasty, Balloon/*adverse effects
MH  - Animals
MH  - Carotid Stenosis/diagnostic imaging/etiology/pathology
MH  - Cell Movement
MH  - Chemokine CCL2/genetics/*physiology
MH  - Constriction, Pathologic
MH  - Electroporation
MH  - Graft Occlusion, Vascular/diagnostic imaging/*etiology/pathology
MH  - Hypercholesterolemia/complications
MH  - Hyperplasia
MH  - Kinetics
MH  - Male
MH  - Monocytes/physiology
MH  - Muscle, Skeletal
MH  - RNA, Messenger/analysis
MH  - Rabbits
MH  - Ultrasonography
EDAT- 2002/06/19 10:00
MHDA- 2002/06/29 10:01
CRDT- 2002/06/19 10:00
PHST- 2002/06/19 10:00 [pubmed]
PHST- 2002/06/29 10:01 [medline]
PHST- 2002/06/19 10:00 [entrez]
AID - 10.1161/01.cir.0000018603.67989.71 [doi]
PST - ppublish
SO  - Circulation. 2002 Jun 18;105(24):2905-10. doi: 
      10.1161/01.cir.0000018603.67989.71.