PMID- 12071156
OWN - NLM
STAT- MEDLINE
DCOM- 20021106
LR  - 20190906
IS  - 0340-3696 (Print)
IS  - 0340-3696 (Linking)
VI  - 294
IP  - 1-2
DP  - 2002 Mar
TI  - Characterization of the inflammatory infiltrate and expression of endothelial 
      cell adhesion molecules in lupus erythematosus tumidus.
PG  - 6-13
AB  - Lupus erythematosus tumidus (LET) is a disease with characteristic clinical and 
      histopathologic features that has not always been considered a subset of 
      cutaneous lupus erythematosus (CLE). Although LET was first mentioned in the 
      literature in 1930, it has rarely been documented, and immunohistochemical 
      studies have never been performed. The aim of the present study was to 
      characterize the inflammatory infiltrate and to analyze the expression of 
      endothelial cell adhesion molecules in skin specimens from patients with LET and 
      to compare the results with those from patients with other variants of CLE, such 
      as discoid lupus erythematosus (DLE) and subacute cutaneous lupus erythematosus 
      (SCLE). Cryostat sections of lesional skin specimens from ten patients with LET 
      demonstrated an infiltrate composed of more than 75% CD4+, CD8+, and HLA-DR+ 
      cells. Interestingly, CD45RO+ cells, in contrast to CD45RA+ cells, were the 
      prevailing inflammatory cell population. Compared with skin specimens from 
      patients with DLE and SCLE, the mean expression of CD4+ and CD8+ cells was higher 
      (but not significantly so) in LET, and no differences were observed with the 
      other three antibodies. Furthermore, in contrast to controls, intercellular 
      adhesion molecule-1, vascular adhesion molecule-1, E-selectin, and P-selectin 
      showed the same expression pattern in skin specimens from patients with DLE, 
      SCLE, and LET. In conclusion, the inflammatory infiltrate of LET primarily 
      consists of CD4+/CD8+ lymphocytes. Furthermore, expression of endothelial cell 
      adhesion molecules was equally upregulated in LET compared with the expression in 
      DLE and SCLE, suggesting a similar immunopathomechanism of these subtypes of CLE.
FAU - Kuhn, Annegret
AU  - Kuhn A
AD  - Institute of Cell Biology, ZMBE, Westfalische Wilhelms-University, Munster, 
      Germany. kuhnan@uni-muenster.de
FAU - Sonntag, Monika
AU  - Sonntag M
FAU - Lehmann, Percy
AU  - Lehmann P
FAU - Megahed, Mosaad
AU  - Megahed M
FAU - Vestweber, Dietmar
AU  - Vestweber D
FAU - Ruzicka, Thomas
AU  - Ruzicka T
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Arch Dermatol Res
JT  - Archives of dermatological research
JID - 8000462
RN  - 0 (CD4 Antigens)
RN  - 0 (CD8 Antigens)
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (E-Selectin)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (P-Selectin)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
RN  - EC 1.4.3.21 (AOC3 protein, human)
RN  - EC 1.4.3.21 (Amine Oxidase (Copper-Containing))
RN  - EC 3.1.3.48 (Leukocyte Common Antigens)
SB  - IM
MH  - Amine Oxidase (Copper-Containing)/analysis/metabolism
MH  - Biopsy
MH  - CD4 Antigens/analysis
MH  - CD8 Antigens/analysis
MH  - Cell Adhesion Molecules/analysis/metabolism
MH  - E-Selectin/analysis/metabolism
MH  - Female
MH  - HLA-DR Antigens/analysis
MH  - Humans
MH  - Immunohistochemistry
MH  - Intercellular Adhesion Molecule-1/analysis/*metabolism
MH  - Leukocyte Common Antigens/analysis
MH  - Lupus Erythematosus, Cutaneous/*metabolism/pathology
MH  - Male
MH  - Middle Aged
MH  - P-Selectin/analysis/metabolism
MH  - Skin/immunology/*metabolism/pathology
MH  - T-Lymphocytes/immunology/pathology
EDAT- 2002/06/20 10:00
MHDA- 2002/11/26 04:00
CRDT- 2002/06/20 10:00
PHST- 2002/06/20 10:00 [pubmed]
PHST- 2002/11/26 04:00 [medline]
PHST- 2002/06/20 10:00 [entrez]
AID - 10.1007/s00403-001-0286-7 [doi]
PST - ppublish
SO  - Arch Dermatol Res. 2002 Mar;294(1-2):6-13. doi: 10.1007/s00403-001-0286-7.