PMID- 12071345
OWN - NLM
STAT- MEDLINE
DCOM- 20021028
LR  - 20190922
IS  - 1071-5762 (Print)
IS  - 1029-2470 (Linking)
VI  - 36
IP  - 3
DP  - 2002 Mar
TI  - Liver necrosis induced by acute intraperitoneal ethanol administration in aged 
      rats.
PG  - 269-75
AB  - It is generally agreed that the deleterious pathophysiological effects of ethanol 
      are caused, at least partially by an increase in free radical production. 
      However, little attention has been directed to the effects of ethanol upon 
      elderly organisms. Male Wistar rats at ages 3, 6, 12, 18 and 24 months were 
      treated either with a single i.p. dose of 35% ethanol (v/v) at 3 g ethanol/kg 
      body weight or an isovolumetric amount of 0.9% saline solution. We then assessed 
      the plasma levels of transaminases and hepatic levels of oxidative stress-related 
      parameters, followed by liver histological evaluation. The younger rats (3 months 
      old) were not affected by the treatment with ethanol with respect to any of the 
      studied parameters except for a lowering of total hepatic GSH and an increase in 
      hepatic thiobarbituric acid reactants (TBARS) formation, while animals older than 
      3 months were increasingly more affected by the treatment. Acute ethanol 
      treatment elicited the similar responses to those in the 3 months-old group, plus 
      a decrease in the hepatic and plasma levels of beta-carotene and the plasma level 
      of alpha-tocopherol, as well as an increase in the activity of plasma 
      transaminases. In the 12,18 and 24 months old groups, there was increasing liver 
      necrosis. These findings suggest that liver damage induced by acute ethanol 
      administration in elderly rats may involve a lack of antioxidants.
FAU - Giavarotti, Leandro
AU  - Giavarotti L
AD  - Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, 
      Brazil. junqueira-geriat@pesquisa.epm.br
FAU - D'Almeida, Vania
AU  - D'Almeida V
FAU - Giavarotti, Karin A S
AU  - Giavarotti KA
FAU - Azzalis, Ligia A
AU  - Azzalis LA
FAU - Rodrigues, Luciano
AU  - Rodrigues L
FAU - Cravero, Amerys A M
AU  - Cravero AA
FAU - Videla, Luis A
AU  - Videla LA
FAU - Koch, Osvaldo R
AU  - Koch OR
FAU - Junqueira, Virginia B C
AU  - Junqueira VB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Free Radic Res
JT  - Free radical research
JID - 9423872
RN  - 0 (Antioxidants)
RN  - 0 (Oxidants)
RN  - 0 (Thiobarbituric Acid Reactive Substances)
RN  - 1406-18-4 (Vitamin E)
RN  - 3K9958V90M (Ethanol)
RN  - 59NEE7PCAB (Hexachlorocyclohexane)
RN  - EC 2.6.1.- (Transaminases)
SB  - IM
MH  - Aging/*drug effects/metabolism
MH  - Animals
MH  - Antioxidants/analysis
MH  - Body Weight
MH  - Ethanol/*administration & dosage/blood
MH  - Hexachlorocyclohexane/administration & dosage/*pharmacology
MH  - Injections, Intraperitoneal
MH  - Liver/*drug effects/metabolism
MH  - Liver Cirrhosis, Alcoholic/*etiology/metabolism/pathology
MH  - Male
MH  - Organ Size
MH  - Oxidants/*analysis
MH  - Rats
MH  - Rats, Wistar
MH  - Thiobarbituric Acid Reactive Substances
MH  - Transaminases/metabolism
MH  - Vitamin E/analysis
EDAT- 2002/06/20 10:00
MHDA- 2002/10/29 04:00
CRDT- 2002/06/20 10:00
PHST- 2002/06/20 10:00 [pubmed]
PHST- 2002/10/29 04:00 [medline]
PHST- 2002/06/20 10:00 [entrez]
AID - 10.1080/10715760290019282 [doi]
PST - ppublish
SO  - Free Radic Res. 2002 Mar;36(3):269-75. doi: 10.1080/10715760290019282.