PMID- 12072017
OWN - NLM
STAT- MEDLINE
DCOM- 20020910
LR  - 20190901
IS  - 0307-6938 (Print)
IS  - 0307-6938 (Linking)
VI  - 27
IP  - 3
DP  - 2002 May
TI  - AL amyloidosis is not present as an incidental finding in cutaneous biopsies of 
      patients with multiple myeloma.
PG  - 240-2
AB  - Multiple myeloma (MM) is a monoclonal B-cell neoplasm characterized by autonomous 
      proliferation of immunoglobulin-secreting plasma cells that are capable of 
      synthesizing amyloidogenic light chains resulting in AL amyloidosis. Clinically 
      occult AL amyloid deposition may occur in up to 31% of patients with MM. The 
      prognosis of combined amyloidosis and MM is improving with new therapeutic 
      options. Thus it is imperative that patients with MM be screened for amyloidosis. 
      Sixty-six consecutive skin biopsies from patients with MM and the diagnosis of 
      graft vs. host disease (GVHD) were stained with Congo red and assessed for the 
      presence of amyloid deposition. Twelve cases that had amyloid deposition in other 
      tissue and had a cutaneous biopsy were also stained with Congo red and assessed 
      for the presence of amyloid deposition. None of the 66 biopsies of GVHD, and none 
      of the 12 cases that had documented amyloid deposition in other tissue showed 
      evidence of amyloid deposition in the cutaneous biopsies. In the absence of 
      specific cutaneous manifestations of amyloidosis, it is unlikely that 
      amyloidogenic light chain deposition in the skin would be found. Type I collagen 
      may appear similar to amyloid, both by light microscopy and fluorescence, after 
      staining with Congo red. Thus care must be taken not to confuse type I collagen 
      autofluorescence with positivity for amyloid when assessing skin biopsies stained 
      with Congo red.
FAU - Bayer-Garner, I B
AU  - Bayer-Garner IB
AD  - Department of Pathology, University of Arkansas for Medical Sciences, Little Rock 
      72205, USA.
FAU - Smoller, B R
AU  - Smoller BR
LA  - eng
PT  - Journal Article
PL  - England
TA  - Clin Exp Dermatol
JT  - Clinical and experimental dermatology
JID - 7606847
SB  - IM
MH  - Amyloidosis/*etiology
MH  - Biopsy
MH  - Graft vs Host Disease/pathology
MH  - Humans
MH  - Multiple Myeloma/*complications/pathology
MH  - Paraneoplastic Syndromes/*etiology
MH  - Skin/pathology
MH  - Skin Diseases/*etiology
EDAT- 2002/06/20 10:00
MHDA- 2002/09/11 10:01
CRDT- 2002/06/20 10:00
PHST- 2002/06/20 10:00 [pubmed]
PHST- 2002/09/11 10:01 [medline]
PHST- 2002/06/20 10:00 [entrez]
AID - 1022 [pii]
AID - 10.1046/j.1365-2230.2002.01022.x [doi]
PST - ppublish
SO  - Clin Exp Dermatol. 2002 May;27(3):240-2. doi: 10.1046/j.1365-2230.2002.01022.x.