PMID- 12075001
OWN - NLM
STAT- MEDLINE
DCOM- 20021210
LR  - 20191210
IS  - 1072-0502 (Print)
IS  - 1072-0502 (Linking)
VI  - 9
IP  - 3
DP  - 2002 May-Jun
TI  - A new group-training procedure for habituation demonstrates that presynaptic 
      glutamate release contributes to long-term memory in Caenorhabditis elegans.
PG  - 130-7
AB  - In the experiments reported here we have developed a new group-training protocol 
      for assessing long-term memory for habituation in Caenorhabditis elegans. We have 
      replicated all of the major findings of the original single-worm protocol using 
      the new protocol: (1) distributed training produced long-term retention of 
      training, massed training did not; (2) distributed training at long interstimulus 
      intervals (ISIs) produced long-term retention, short ISIs did not; and (3) 
      long-term memory for distributed training is protein synthesis-dependent as it 
      could be blocked by heat shock during the inter-block interval. In addition, we 
      have shown that long-term memory for habituation is graded, depending on the 
      number of blocks of stimuli in training. The inter-block interval must be >40 min 
      for long-term retention of training to occur. Finally, we have tested long-term 
      memory for habituation training in a strain of worms with a mutation in a 
      vesicular glutamate transporter in the sensory neurons that transduce tap 
      (eat-4). The results from these eat-4 worms indicate that glutamate release from 
      the sensory neurons has an important role in the formation of long-term memory 
      for habituation.
FAU - Rose, Jacqueline K
AU  - Rose JK
AD  - Department of Psychology and Brain Research Centre, University of British 
      Columbia, Vancouver, British Columbia V6T 1Z4, Canada.
FAU - Kaun, Karla R
AU  - Kaun KR
FAU - Rankin, Catharine H
AU  - Rankin CH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Learn Mem
JT  - Learning & memory (Cold Spring Harbor, N.Y.)
JID - 9435678
RN  - 3KX376GY7L (Glutamic Acid)
SB  - IM
MH  - Animals
MH  - Caenorhabditis elegans/*physiology
MH  - Conditioning, Psychological/physiology
MH  - Glutamic Acid/*metabolism
MH  - Habituation, Psychophysiologic/*physiology
MH  - Memory/*physiology
MH  - Presynaptic Terminals/metabolism
MH  - Synaptic Transmission/physiology
PMC - PMC182588
EDAT- 2002/06/21 10:00
MHDA- 2002/12/11 04:00
PMCR- 2003/05/01
CRDT- 2002/06/21 10:00
PHST- 2002/06/21 10:00 [pubmed]
PHST- 2002/12/11 04:00 [medline]
PHST- 2002/06/21 10:00 [entrez]
PHST- 2003/05/01 00:00 [pmc-release]
AID - 10.1101/lm.46802 [doi]
PST - ppublish
SO  - Learn Mem. 2002 May-Jun;9(3):130-7. doi: 10.1101/lm.46802.