PMID- 12077712
OWN - NLM
STAT- MEDLINE
DCOM- 20020827
LR  - 20191025
IS  - 0049-0172 (Print)
IS  - 0049-0172 (Linking)
VI  - 31
IP  - 6
DP  - 2002 Jun
TI  - TAP, HLA-DQB1, and HLA-DRB1 polymorphism in Colombian patients with primary 
      Sjogren's syndrome.
PG  - 396-405
AB  - OBJECTIVE: Although primary Sjogren's syndrome (pSS) has a worldwide 
      distribution, little data is available on pSS immunogenetics in non-white 
      populations. Thus, we investigated the influence of transporters associated with 
      antigen processing (TAP), human leukocyte antigen (HLA)-DQB1, and HLA-DRB1 gene 
      polymorphism in mestizo Colombian patients with pSS. METHODS: In this 
      cross-sectional and controlled study, all patients met the European criteria for 
      classification of pSS. TAP and HLA typing was performed by polymerase chain 
      reaction techniques. Genetic data analysis was performed to detect deviations 
      from the expected Hardy-Weinberg (H-W) proportions and to determine the presence 
      of population stratification or subdivision and the existence of linkage 
      disequilibrium between pairs of loci. RESULTS: Seventy-three Colombian patients 
      with pSS (95% women) and 76 healthy controls were studied. Although significant 
      associations were not observed between TAP or HLA polymorphism and disease, 
      strong linkage disequilibrium among the loci TAP2 and DQB1 was found in patients. 
      Deviations from the H-W expected value were found in the DQB1 locus of patients 
      (P =.02). HLA-DRB1*0301-DQB1*0201 haplotype was associated with more severe 
      histopathologic disease (odds ratio [OR], 15.5; 95% confidence interval [CI], 
      1.9-129; P =.001) and the presence of anti-Ro (OR, 3.8; 95% CI, 1-15; P =.04) and 
      anti-La antibodies (OR, 4.3; 95% CI, 1.3-14; P =.01). CONCLUSION: The data show 
      genetic evidence suggesting that, in Colombians, a region immersed or in the 
      vicinity in the HLA class II system is strongly associated with a predisposition 
      to acquire pSS, which is probably located between the TAP2 and HLA-DQB1 locus. 
      Our results confirm that the HLA-DRB1*0301-DQB1*0201 haplotype participates in 
      the pathogenesis of pSS.
CI  - Copyright 2002, Elsevier Science (USA). All rights reserved.
FAU - Anaya, Juan-Manuel
AU  - Anaya JM
AD  - Rheumatology Unit, Corporacion para Investigaciones Biologicas (CIB), Medellin, 
      Colombia. jmanaya@epm.net.co
FAU - Correa, Paula A
AU  - Correa PA
FAU - Mantilla, Ruben D
AU  - Mantilla RD
FAU - Arcos-Burgos, Mauricio
AU  - Arcos-Burgos M
LA  - eng
PT  - Clinical Trial
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Semin Arthritis Rheum
JT  - Seminars in arthritis and rheumatism
JID - 1306053
RN  - 0 (ATP Binding Cassette Transporter, Subfamily B, Member 2)
RN  - 0 (ATP Binding Cassette Transporter, Subfamily B, Member 3)
RN  - 0 (ATP-Binding Cassette Transporters)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*03:01 antigen)
RN  - 0 (TAP1 protein, human)
RN  - 145892-13-3 (TAP2 protein, human)
SB  - IM
MH  - ATP Binding Cassette Transporter, Subfamily B, Member 2
MH  - ATP Binding Cassette Transporter, Subfamily B, Member 3
MH  - ATP-Binding Cassette Transporters/*genetics
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Child
MH  - Colombia
MH  - Cross-Sectional Studies
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Histocompatibility Testing
MH  - Humans
MH  - Linkage Disequilibrium
MH  - Major Histocompatibility Complex/genetics
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Genetic
MH  - Salivary Glands, Minor/pathology
MH  - Sjogren's Syndrome/*genetics/immunology/pathology
EDAT- 2002/06/22 10:00
MHDA- 2002/08/28 10:01
CRDT- 2002/06/22 10:00
PHST- 2002/06/22 10:00 [pubmed]
PHST- 2002/08/28 10:01 [medline]
PHST- 2002/06/22 10:00 [entrez]
AID - S0049017202000057 [pii]
AID - 10.1053/sarh.2002.32557 [doi]
PST - ppublish
SO  - Semin Arthritis Rheum. 2002 Jun;31(6):396-405. doi: 10.1053/sarh.2002.32557.