PMID- 12077714
OWN - NLM
STAT- MEDLINE
DCOM- 20020827
LR  - 20191025
IS  - 0049-0172 (Print)
IS  - 0049-0172 (Linking)
VI  - 31
IP  - 6
DP  - 2002 Jun
TI  - Psoriatic spondyloarthropathy: a comparative study between HLA-B27 positive and 
      HLA-B27 negative disease.
PG  - 413-8
AB  - OBJECTIVES: To evaluate the relative contribution of the human leukocyte antigen 
      (HLA)-B27 to psoriatic spondyloarthropathy (PsSpA) susceptibility and to analyze 
      whether this antigen contributes to disease expression. METHODS: This 
      cross-sectional study included 70 patients (mean age 48 +/- 14.5 years; 44 men 
      and 26 women). PsSpA was defined according to radiological findings (grade 2 or 
      more sacroiliitis), and patients were classified into 3 main subtypes: isolated 
      axial disease (n = 16), axial plus oligoarthritis (n = 29) and axial plus 
      polyarthritis (n = 25). All patients were studied following a standard protocol 
      that included the collection of demographic and epidemiological data, clinical 
      history, radiographs, complementary tests, physical examination, and HLA-B27 
      testing (serological method). For functional evaluation, the Health Assessment 
      Questionnaire-Specific for spondyloarthropathy (HAQ-S) was used. Patients with 
      and without HLA-B27 antigen were compared on the basis of the data. RESULTS: 
      Twenty-four patients (34%) carried the HLA-B27 antigen (RR 6.4, P <.0004). 
      Fifty-six percent of those patients with the isolated axial pattern had this 
      antigen, compared with 24% in the poly-arthritis axial pattern and 31% of those 
      in the oligo-arthritis axial group (P =.016). Univariate analysis demonstrated 
      correlations between HLA-B27 and an earlier age of onset for both psoriasis (P 
      =.028) and arthritis (P =.006), male gender (P =.002), bilateral sacroiliitis (P 
      =.002), and uveitis (P =.026). HLA-B27 negative patients developed more 
      peripheral erosions than HLA-B27 positive patients (P =.05). No correlation was 
      found between B27 and clinical symptoms of back involvement, syndesmophytes, or 
      functional impairment. CONCLUSIONS: The HLA-B27 antigen is not only important for 
      PsSpA susceptibility, but also determines some clinical features. This antigen 
      was associated with earlier age of psoriasis and arthritis onset, bilateral 
      sacroiliitis, and male gender. However, it was not associated with either the 
      severity or extension of the spondylitic process or with functional impairment.
CI  - Copyright 2002, Elsevier Science (USA). All rights reserved.
FAU - Queiro, Ruben
AU  - Queiro R
AD  - Rheumatology Unit, Hospital San Agustin, Aviles-Asturias, Spain. 
      ruquei@mixmail.com
FAU - Sarasqueta, Cristina
AU  - Sarasqueta C
FAU - Belzunegui, Joaquin
AU  - Belzunegui J
FAU - Gonzalez, Carlos
AU  - Gonzalez C
FAU - Figueroa, Manuel
AU  - Figueroa M
FAU - Torre-Alonso, Juan C
AU  - Torre-Alonso JC
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Semin Arthritis Rheum
JT  - Seminars in arthritis and rheumatism
JID - 1306053
RN  - 0 (HLA-B27 Antigen)
SB  - IM
MH  - Arthritis, Psoriatic/*immunology/pathology/physiopathology
MH  - Cross-Sectional Studies
MH  - Female
MH  - HLA-B27 Antigen/*analysis
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Sacroiliac Joint/pathology
MH  - Serologic Tests
MH  - Severity of Illness Index
MH  - Uveitis/pathology
EDAT- 2002/06/22 10:00
MHDA- 2002/08/28 10:01
CRDT- 2002/06/22 10:00
PHST- 2002/06/22 10:00 [pubmed]
PHST- 2002/08/28 10:01 [medline]
PHST- 2002/06/22 10:00 [entrez]
AID - S0049017202000070 [pii]
AID - 10.1053/sarh.2002.33470 [doi]
PST - ppublish
SO  - Semin Arthritis Rheum. 2002 Jun;31(6):413-8. doi: 10.1053/sarh.2002.33470.