PMID- 12078454
OWN - NLM
STAT- MEDLINE
DCOM- 20030429
LR  - 20061115
IS  - 0375-0906 (Print)
IS  - 0375-0906 (Linking)
VI  - 66
IP  - 4
DP  - 2001 Oct-Dec
TI  - [Hypertensive inferior esophageal sphincter. Prevalence and clinico-manometric 
      features].
PG  - 174-8
AB  - BACKGROUND: The hypertensive lower esophageal sphincter (HLES) is an unusual 
      primary motor disorder of the esophagus. The lack of a precise definition has 
      made it difficult to establish its prevalence and its clinical and manometric 
      characteristics. OBJECTIVES: 1) To determine the prevalence of HLES using precise 
      diagnostic criteria, 2) To identify the clinical manifestations of this disease, 
      and 2) To compare manometric findings in patients with HLES against normal 
      subjects. METHODS: A total of 705 consecutive esophageal manometries were 
      performed over 52 months. HLES was defined as basal pressure 45 > or = mmHg, 
      normal relaxation in response to swallowing, and normal peristalsis of the 
      esophageal body. Clinical records were reviewed to identify the main symptoms 
      that prompted the manometry. The manometric data of patients with HLES was 
      compared to that of 16 healthy control subjects. RESULTS: Seven HLES patients 
      were identified establishing a prevalence of 1%. Four HLES cases were referred 
      due to dysphagia, two due to symptoms of gastroesophageal reflux disease, and one 
      due to thoracic pain. Upon comparing manometric data of patients with HLES and 
      healthy control subjects the motor function of the esophageal body, the total 
      length of the lower esophageal sphincter, and its position in respect to the 
      diaphragm were similar in both groups. CONCLUSIONS: Prevalence of HLES was 1%. 
      Dysphagia was the main symptom. Total length of the sphincter, as well as length 
      of the thoracic and abdominal segments do not appear to contribute to high basal 
      pressure.
FAU - Carmona-Sanchez, R
AU  - Carmona-Sanchez R
AD  - Servicio de Gastroenterologia, Departamento de Medicina Interna, Hospital Central 
      Dr. Ignacio Morones Prieto, San Luis Potosi, S.L.P. rcarmonas@prodigy.net.mx
FAU - Valerio-Urena, J
AU  - Valerio-Urena J
FAU - Valdovinos-Diaz, M A
AU  - Valdovinos-Diaz MA
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - El esfinter esofagico inferior hipertenso. Prevalencia y caracteristicas 
      clinicomanometricas.
PL  - Mexico
TA  - Rev Gastroenterol Mex
JT  - Revista de gastroenterologia de Mexico
JID - 0404271
SB  - IM
MH  - Adult
MH  - Esophageal Motility Disorders/*epidemiology/*physiopathology
MH  - Esophagogastric Junction/*physiopathology
MH  - Female
MH  - Humans
MH  - Male
MH  - Manometry
MH  - Middle Aged
MH  - Pressure
MH  - Prevalence
EDAT- 2002/06/25 10:00
MHDA- 2003/04/30 05:00
CRDT- 2002/06/25 10:00
PHST- 2002/06/25 10:00 [pubmed]
PHST- 2003/04/30 05:00 [medline]
PHST- 2002/06/25 10:00 [entrez]
PST - ppublish
SO  - Rev Gastroenterol Mex. 2001 Oct-Dec;66(4):174-8.